Starting the day at 102, West Indies captain Kraigg Brathwaite ended his innings at 160. The hosts were finally all out for 411.
With his 119 not out in Barbados, Joe Root scored two-consecutive hundreds against West Indies in the series. He had scored 109 on drawn first Test.
In reply to England’s 311, West Indies were 127/4 at one stage before Jason Holder and Nkrumah Bonner stitched 75 runs for the unbroken fifth stand.
West Indies were 288/4 at the end of Day 3 in reply to England’s first innings total of 507/9 decl. the first Test ended in a draw.
West Indies were penalised two points in the WTC standings that dropped them below Bangladesh to eighth in the nine-team standings.
Jonny Bairstow was involved in three fifty-plus partnerships as England rose from 48/4 to end the day at 268/6 in Antigua.
After Joe Root, Ben Stokes scored a free-flowing 120 from 128 balls to put England in a strong position at the end of Day 2.