This is the 154th meeting between the two teams. England lead South Africa 64-34 in the head-to-head record. England have also won the three outings against the Proteas. In fact, England are 7-3 in the last ten matches against South Africa.
The last time the two teams met at Lord's, England beat South Africa by 211 runs in 2017.
England: Zak Crawley, Alex Lees, Ollie Pope, Joe Root, Jonny Bairstow, Ben Stokes (c), Ben Foakes, Stuart Broad, Jack Leach, Matthew Potts, James Anderson.
South Africa: Dean Elgar, Sarel Erwee, Keegan Petersen, Aiden Markram, Rassie van der Dussen, Kyle Verreynne, Keshav Maharaj, Marco Jansen, Kagiso Rabada, Lungi Ngidi, Anrich Nortje.
The Proteas won the preceding three-match T20I series 2-1, while the tour-opening ODIs ended in a 1-1 draw.