Ben Dwarshuis took three wickets and Australia's middle order turned on the style with the bat in a three-wicket win over West Indies.
West Indies performed respectably with the bat, reaching 173-7 from their 20 overs.
Dwarshuis took 3-41 before quickfire knocks from Cameron Green (32), Tim David (30) and Mitchell Owen (37) helped propel Australia to a 5-0 series whitewash.
Shimron Hetmyer hit a 31-ball 52 before he fell to Dwarshuis, while Sherfane Rutherford contributed 35.
Early dismissals of Mitchell Marsh (14), Glenn Maxwell (0) and Josh Inglis (10) gave the Windies hope of ending the series on a high note, but the tourists' middle order then took hold.
David reeled off four sixes as he reached 30 from just 12 balls before succumbing to Alzarri Joseph (2-21), with Green and Owen then steering Australia to 123 before the latter was sent packing by Akeal Hosein (3-17).
Hosein also did for Green and Dwarshuis (nine), but Aaron Hardie (28 not out) and Sean Abbott (five not out) fended off the Windies' attack to wrap up victory with three overs to spare.
Data Debrief: A flip of the coin
Australia captain Marsh won the toss in Basseterre. In the eight matches (three Tests, five T20Is) across the series, Marsh won each of the tosses, and on each occasion, he made a good call when it came to deciding who to put into bat.
West Indies did their best to prove him wrong this time, with Hetmyer making his first half-century in the shortest format since August 2023.
Dwarshuis was on point with the ball, other than a costly final over, while Adam Zampa (1-20) marked his 100th T20I with a wicket. He is the fourth Australian man to reach that landmark in the format.
Australia have won a T20I series 5-0 for the first time, while on the flip side, it is the first time the Windies have ever been whitewashed 5-0 in such a series.