Eddie Nketiah scored twice after Mohamed Elneny’s opener, with all of the league leader’s goals coming in the space of 13 second-half minutes at an atmospheric Kassam Stadium.
The European rivals seemed destined for a win-and-advance final group stage match ever since the tournament draw in April placed them in Group G with heavily favored Brazil.
Arsenal now hold a two-point lead over Manchester City in the Premier League 2022-23 table. Granit Xhaka was the scorer for the Gunners.
Tensions flared in the stands and on the field in a rematch of Serbia and Switzerland's stormy game at the 2018 World Cup that revived ethnic Balkan rivalries.
Breel Embolo’s goal lifted Switzerland to a 1-0 win over Cameroon at the World Cup on Thursday and he kept his promise not to celebrate scoring against the country where he was born.
Gabriel Jesus signed for Arsenal from Manchester City. Granit Xhaka and Gabriel Martinelli scored the other two goas for Arsenal against Leicester City in Premier League 2022-23.
The former Manchester United star might be the first player to score a goal at five World Cups, but since converting that penalty in Portugal's opening game, Cristiano Ronaldo has had a rather quiet time of it.
Portugal have a slight head-to-head advantage over Switzerland. Get the live streaming details of UEFA Nations League 2022-23 match.
Arsenal will host Everton and know a win still might not be enough to get back in the Champions League after a five-year absence.
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