The veteran actor married his frequent co-star then Jaya Bhaduri on June 3, 1973. They share two children -- author Shweta Bachchan Nanda and actor Abhishek Bachchan.
A day after their 50th wedding anniversary, Amitabh Bachchan thanked well-wishers for their love in a brief note shared on his personal blog.
"My deepest gratitude for all that have wished Jaya and me for our 50th Anniversary .. your love and care is what gives us the most happiness .." the 80-year-old wrote.
"At work now .. later .." he added in the post.
On June 2, Amitabh Bachchan talked about the upcoming milestone occasion.
"June 3 dawns in a few .. and the years be counted as 50 .. love respect and gratitude for the wishes , that have come and perhaps shall come .. (sic)" he had posted on his blog.
Abhishek Bachchan had shared a series of throwback pictures of his parents on his Instagram account to mark his parents' golden jubilee.
"Adding to the list of the many Golden Jubilees to their credit... But this is by far the most special one. Happy 50th wedding anniversary Ma and Pa!" he wrote.
Shweta Bachchan Nanda had posted a monochrome photo of her parents, detailing the secret to a long marriage.
"Happy 50th parents -- now you're 'Golden'. Once on being asked what the secret to a long marriage is, my mother answered - love, and I think my father's was - the wife is always right. That's the long & short of it!!" she captioned the picture.
Amitabh Bachchan and Jaya Bachchan have acted in several films, including "Zanjeer", "Sholay", "Abhimaan", "Mili", "Chupke Chupke", "Silsila", and "Kabhi Khushi Kabhie Gham".