Does it hurt seeing yourself getting old with each passing day?
The sagging skin, the fine lines and wrinkles on the face, or maybe the lowering of energy to just do ANYTHING like you used to do when you were young...
Umm, that's what aging looks like, I know!
But you don't have to worry anymore about losing yourself in the journey because peptide therapy can act as a time machine for you.
Tune in to know about the TOP anti-aging peptides available in the market and see yourself going back in time.
● Some of the best peptides for anti-aging include Epithalon, Sermorelin, Matrixyl, Argireline, and Palmitoyl Tetrapeptide 7.
● Different anti-aging peptides benefit in different ways. They can either raise the local growth hormone levels leading to a mirage of different benefits or work to rejuvenate skin by upregulating natural collagen production as well as growth factors.
● Anti-aging peptides are either purchased as peptide creams or injectable versions, we detail only injectable here.
What are Peptides?
Peptides are short chains of amino acids that are the building blocks of proteins (1 ). The peptides are considered far superior to the latter due to their rapid absorption and concise structure. Besides, peptides can achieve numerous benefits, such as muscle bulk, a robust immune system, and weight loss.
In addition to this, new peptides are being synthesized to reverse aging. These peptides provide rapid wound healing and contain anti-inflammatory attributes. These peptides aid in removing fine lines and wrinkles from your skin and promote the formation of collagen or hyaluronic acid.
#1 Peptide for Anti-Aging: Epithalon
Epithalon is a classic anti-aging tetrapeptide consisting of 4 amino acids. A renowned Russian scientist Vladimir Khavinson initially discovered the peptide, and since then, most of the studies have been carried out at the St. Petersburg Institute of Bioregulation and Gerontology.
The peptide often uses the phrase 'the fountain of youth' due to its remarkable anti-aging attributes (2). The peptide itself is a synthetic activator of telomerase enzyme. This allows the renewal of telomeres at the end of chromosome chains leading to enhanced cell growth and regeneration/repair of the old ones.
The peptide also improves the sleep cycle and modulates stress levels in teens. 5-10 mg of Epithalon daily for 2-3 weeks is recommended before going off the bike.
● Reverses aging
● Improves sleep cycle
#2 Best For GH release: Sermorelin
As you age, your body's ability to synthesize growth hormones declines. However, with Sermorelin , a 29 amino acid peptide, you've got nothing to worry about. The peptide is an analog of Growth Hormone Secreting Hormone (GHRH) that, after binding to the receptors on the anterior pituitary, causes the release of human growth hormone (3 ).
The peptide improves the sleep cycle and healthy nails and skin, enhances strength and endurance, and boosts our immune system. This leads to a much healthier body and can be used as an anti-aging peptide.
Most sources recommend using 0.2 to 0.3 mcg once before bedtime every day. As far as cycling is concerned, you can do so for about three months safely. Sermorelin is usually injected subcutaneously.
● Improves muscle mass, and promotes rapid weight loss
● Efficient wound healing
#3 Best For Sagging Skin: Matrixyl
Matrixyl is quite a unique peptide both in structure and function as compared to others. Matrixyl is a pentapeptide composed of 5 amino acids alongside a fatty acid.
One of the primary signs of old age is wrinkling and sagging of the skin. This is due to skin cells not being able to rejuvenate as we age. Matrixyl helps in skin care as it enables the lowermost layer of the skin to revive, thus aiding in eliminating fine lines and wrinkles on the skin and enhancing skin texture (4 ).
The peptide also helps prevent skin regression as it promotes collagen production and upregulates the levels of hyaluronic acid. With hyaluronic acid, you can have a smooth skin texture as well as a uniform skin tone.
Matrixyl is essentially a very safe option for all types of skin, including sensitive skin and acne-prone skin, with negligible side effects.
● Reduces fine lines and wrinkles
● Gives you an even skin tone
#4 Best For Weight Loss: Argireline
Argireline is a well-known peptide for its anti-aging benefits. However, unlike Matrixyl, Argirelin doesn't promote collagen or hyaluronic acid production.
Argireline is a type of hexapeptide that is specifically beneficial when it comes to weight loss.
Nonetheless, Argirelin has one unique attribute. The peptide relaxes the facial muscles and is renowned for its rapid and profound effects.
As we age, there is an appearance of fine lines and wrinkles, but with this peptide, one can reduce fine facial lines alongside having smoother and plumper skin and look young for your age (5).
● Reduces fine lines with facial muscle relaxation
● Weight loss peptide
#5 Best To Boost Collagen Production: Palmitoyl Tetrapeptide-7
Adding Palmitoyl Tetrapeptide-7 to your daily skincare routine would be ideal incorporation. Palmitoyl Tetrapeptide consists of 4 amino acids linked together via a palmitic acid molecule. Palmitic acid being lipid soluble, easily diffuses through our skin alongside slipping the peptides past our natural defenses, aka our skin barrier.
The peptide is known to work by stimulating new molecules for a complete skin makeover. Besides this, Palmitoyl Tetrapeptide-7 also boosts collagen and hyaluronic acid production, thus giving you firmer skin (6).
Interestingly, the peptide markedly reduces inflammation and swelling of the skin as well.
With this peptide, you can expect reduced wrinkles and fine lines of the skin after a few doses.
● Reduces inflammation and swelling
● Easily passes through the skin
How do Peptides for Anti-Aging Work?
Almost everyone around us is looking for ways to eliminate those extra skin lines or wrinkles on their faces. However, cosmetic surgery costs a fortune if its just for anti-aging effects. This is where peptide therapy steps in!
Peptides are small chains of amino acids that can help promote collagen and elastin production, which are responsible for skin integrity. With increased collagen and elastin levels, a healthy skin barrier is maintained that prevents dust or harmful pollutants from affecting our skin.
Besides this, peptides also stimulate angiogenesis and renewal of old cells. With anti-aging peptide therapy, you can also have a strengthened immune system that keeps your body healthy and fights off infections relatively efficiently.
Topical peptides can specifically target skin wrinkles and close off pores.
How To Use Peptides?
Most of the peptides come in either injectable or oral forms.
Nonetheless, when it comes to anti-aging peptides, they usually come in the form of peptide serums or topical creams. You can also expect these peptides as transdermal patches.
For injectable anti-aging peptides, you must be very careful. For this, one has to reconstitute the peptide first before injecting it. For reconstitution, visit here .
Are Peptides Legal?
In the United States, the FDA has yet to approve most peptides for human consumption. Most peptides can only be sold for research purposes or clinical trials.
Are Peptides Safe?
It's understandable to be paranoid before trying out any new drug or supplement, especially if it involves fewer clinical trials involving humans. Nonetheless, peptides are still considered very safe and have shown some promising results.
Besides some abdominal discomfort, headache, and nausea, it's infrequent for adverse reactions to occur. Still, it's essential to abide by the correct dosage and stay within that.
What peptides can be used for Anti-aging?
You can use Epitalon, Sermorelin, Ipamorelin/CJC 1295, or Thymosin Alpha 1 for anti-aging.
Are peptides safe for humans?
So far, it is rare for someone to experience adverse reactions due to peptide use. However, mild side effects such as abdominal discomfort are common after peptide usage.
1- Forbes J, Krishnamurthy K. Biochemistry, Peptide. 2022 Aug 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32965931.
2- Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. doi: 10.1023/a:1025114230714. PMID: 14501183.
3- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.
4- Kachooeian M, Mousivand Z, Sharifikolouei E, et al. Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing. ACS Omega. 2022;7(28):24695-24704. Published 2022 Jul 11. doi:10.1021/acsomega.2c02592
5- Wang, Yuan et al. “The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.” American journal of clinical dermatology vol. 14,2 (2013): 147-53. doi:10.1007/s40257-013-0009-9
6-Resende, Diana I S P et al. “Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.” Pharmaceuticals (Basel, Switzerland) vol. 14,8 702. 21 Jul. 2021, doi:10.3390/ph14080702
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