5 Best Peptides For Healing (Joint and Tissue Repair) + Sources

Hey there, fellow fitness freaks! Did you know that peptides aren't just for getting ripped? It's true! These little miracle workers are like the Swiss Army knife of human health, and can even help you recover from injuries faster than a superhero.

I mean, sure, bodybuilders and athletes have been using peptides for years to treat joint and tendon issues, but they're not the only ones who can benefit. Even your grandma could use some BPC-157 to kick her arthritis to the curb.

And don't even get me started on the stats. Did you know that the global peptide therapeutics market is expected to be worth more than Jeff Bezos' bank account by 2025? That's right, these tiny peptides are taking the medical world by storm.

So, if you're looking to improve your health, heal an injury, or just feel like a superhero, give these peptides a shot. You might just be surprised at how much they can do. Plus, who doesn't want to be a superhero?

Key Takeaways

Many body protection compounds are present that aid in the healing and recovery process of joints and connective tissue repair.

These peptides include BPC-157, TB-500, Epithalon, Glutamine, and MGF.

These peptides primarily enhance angiogenesis, muscle growth, and hypertrophy, improve bone density, and act as anti-inflammatory mediators.

This article includes descriptions of these peptides, their recommended dosage, where to buy, and how to reconstitute peptides safely.

The information in this article is intended for informational and entertainment purposes only. It is not a substitute for professional medical advice. Prior to purchase, ensure compliance with current government laws.

How To Use Peptides to Heal Injuries?

There are various forms of peptides with their therapeutic bioavailability, indications, and contraindications. Most of these peptides come in injectable forms, whereas it's common to find them in oral, liquid, powder, nasal sprays, transdermal patches, or topical applications.

Nevertheless, special consideration is required for the injectable ones. Before using this form, it's fundamental to properly reconstitute the peptide carefully as per the dosage guidelines. This can be done by carefully adding drops of bacteriostatic water to the peptide-containing vial.

After this, keep the vial in favorable conditions for reuse. Once done, you can carefully inject the peptide via one of the three routes of admission, i.e., Subcutaneous, Intravenous, and Intramuscular.

What are Peptides?

Peptides are composed of small chains of amino acids, forming the very foundation of proteins (1). Most of these peptides are the derivatives of naturally found compounds inside the human body or are synthesized from scratch in laboratories.

Due to their concise structure, these peptides are easily absorbed in our blood, leading to greater bioavailability. So, what exactly are peptides used for?

For most, peptides are a means of gaining bulky muscles, bone strength, greater endurance, and a good-looking physique. However, peptides are not just that. Over the years, peptides have also been used for healing and recovery due to their wound-healing capabilities, anti-inflammatory advantages, and enhanced immune response.

#1 Peptide For Rapid Wound Healing Process: BPC-157

BPC-157 is one of the few efficacious body protection compounds, amongst others. The 15 amino acids that make up this pentadecapeptide are arranged in quite an unusual way and are thus not found in nature (2). BPC-157's curative properties make it the most preferred healing compound in the fitness industry.

BPC-157 exerts its beneficial effects via a range of diverse mechanisms.

For starters, the peptide promotes the process of angiogenesis (formation of new blood vessels) in the human body. This allows the injured tissue to receive appropriate oxygen content and nutrients for rapid healing. Besides this, BPC-157 downregulates one anti-growth modulator known as 4-hydroxynonenal (3). This leads to a much faster and more effective recovery.

In addition to the body's recovery mechanisms, BPC-157 promotes a rather constructive repair of joints, ligaments, and tendon injuries.

If you're a beginner, the initial dosing for BPC-157 should be at most 1-10 mcg per kilogram of body weight.

Best For:

Speeds up the healing process

Promotes angiogenesis
Repair of joints, ligaments and tendons

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#2 Best Anti-Inflammatory Peptide: TB-500

If you're looking for an anti-inflammatory peptide that ramps the recovery process, then Thymosin beta 4, aka TB-500, is just for you (4). The peptide is a naturally occurring hormone commonly found in the Thymus gland of the human body, comprising 43 amino acids. TB-500, more appropriately, is a synthetic version of Thymosin beta 4 with more enhanced attributes.

As far as its mode of action is concerned, it's slightly peculiar. TB-500 augments the body's ability to respond to actin filaments via enhancing the reception through (17)LKKTETQ(23) segment of TB-500. This process enables the body to upregulate cell growth, proliferation, and differentiation (usually endothelial cells).

Owing to its anti-inflammatory properties, it ensures smooth repair of the damaged tissue (5).

Besides this, like BPC-157, clinical trials report a boost in angiogenesis when supplemented with TB-500.

For peptide therapy with TB-500, it is recommended to use 5-20 mg of the drug for optimum benefits.

Best For:

Anti-inflammatory peptide
Upregulates cell growth, proliferation and differentiation
Repair of damaged tissues

>> Buy 99%+ Pure Tested TB 500 Here<<

#3 Best Peptide for Anti-Aging: Epithalon

This one is a synthetic tetrapeptide that augments the body's regenerative and protective mechanisms. Vladimir Khavinson, a Russian scientist, first discovered it. Later on, many studies were carried out at the St. Petersburg Institute of Bioregulation and Gerontology.

Essentially, Epithalon is a synthetic activator of telomerase enzymes (6). This means that the peptide enhances the natural production and secretion of the Telomerase enzyme from the pineal gland, which leads to renewed telomeres at the end of chromosomes. This progressively increases the lifespan of cells.

The "fountain of youth" peptide, aka Epithalon, assists in healing from muscle injuries, improves the health of other tissues, and play a critical role in promoting a balanced sleep/wake cycle, and acts as a potent antioxidant and keeps you away from inflammation (7).

It is important to cycle the peptide for at least 2-3 weeks for the desired recovery.

Best For:

Anti-aging peptide
Anti-oxidant properties
Improves sleep cycle

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#4 Best Peptide For Tissue Repair: Glutamine

One can't properly fit L-glutamine in one of the two essential and nonessential amino acid groups. Although synthesized in the human body, Glutamine can become deficient at times of stress and tissue injury when your body needs it the most. Therefore, doctors recommend additional supplementation with the amino acids to keep you fully prepared.

Glutamine is considered the storage molecule for nitrogen and is a critical factor in protein synthesis as well as immune and inflammatory cell activator (8). This means that during tissue and muscle injury recovery, your body uses up the excess stores of Glutamine, leading to its early depletion.

Therefore, Glutamine provides the damaged tissues with nutrients and raw materials like nitrogen for rapid wound healing process by upregulating collagen production.

Best For:

Enhances immune system
Stimulates collagen production
Rapid wound healing

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#5 Alternative Peptide For Tissue Repair: Mechano Growth Factor - MGF

Mechano growth factor is a synthetic derivative of IGF-1, commonly used for tissue repair and muscle growth. The peptide is a potent activator of muscle satellite/stem cells, leading to muscle hypertrophy and regeneration (9,10).

The peptide increases the local growth factors that results in an increased bone density and improves cardiac and vascular function alongside neuroprotective factors. Research also suggests MGF's therapeutic role in healing injured tendons and wound healing.

Studies also reveal its favorable effects in preventing osteoarthritis by protecting cartilage from stress and damage, thus improve joint mobility, and ensure reduced pain.

It is advised to use 200 mcg of MGF per day. One can also stack MGF with other peptides, such as BPC-157 and HGH.

Best For:

Tissue repair and Muscle growth
Cartilage proliferation

Improve joint mobility

>> Buy 99%+ Pure MGF Peptide Here<<

How Do Peptides Heal Injuries?

Ever wondered how exactly these peptides can carry out a diverse range of functions even though they're so small? Besides muscle growth and increased endurance, peptides provide many more benefits than one can imagine. One of these includes rapid healing and tissue repair and regeneration.

Most healing peptides work by increasing angiogenesis, i.e., forming new blood vessels. This provides a direct pathway for the rejuvenating tissues to get nutrients and enough oxygen to heal.

Besides this, peptides often boost our immune system and act as a chemokine for anti-inflammatory cells. This allows our body's protective agent to clear the debris and fight off infection at the earliest so that wound healing can take place.

Healing peptides like TB-500 also enhance the body's reception to actin. This leads to more proliferation and differentiation of cells, especially keratinocytes and endothelial cells.

Some peptides are unique in their mechanism of action, like Epithalon. This one works by stimulating the release of telomerase enzymes.

No matter how distinct peptides are in their mode of action, they all serve the same function.

Are Peptides Legal?

Regarding the legality of peptides, they're currently prohibited for human consumption by the Food and Drugs Administration (FDA). This is due to the need for clinical trials involving human subjects. Nonetheless, one can purchase these peptides for research and clinical purposes.

Are Peptides Safe?

I don't see a reason for making peptides unsafe for human consumption. Compared to other supplements such as SARMs, anabolic steroids, and prohormones, peptides are safe with minimal side effects.

Although limited, clinical studies prove the productive properties of peptides on the human body, especially for healing. Besides mild unpleasant symptoms like headache, nausea, and stomach discomfort with peptide therapy, there's nothing one should worry about.

FAQs on Peptides

What are the best healing peptides?

Some potent healing peptides include TB-500, BPC-157, Epithalon, Glutamine, and MGF.

What are the benefits of healing peptides?

Besides causing regenerative and repair properties, healing peptides also increase angiogenesis, relief from joint pain and improving joint mobility, muscle growth, and improved bone density.

Do peptides have side effects?

Yes! Like other supplements, peptides too have side effects like nausea, stomach discomfort, and headaches. However, these are often mild and go away in a few hours to days.

Where can I get these peptides?

One can easily purchase peptides from credible online vendors. These include Biotech Peptides and The Sports Laboratory.

Are peptides similar to steroids?

No! Peptides and steroids are poles apart. Steroids unnaturally increase testosterone, whereas peptides work by signaling these hormones' stimulation.

References:

Forbes J, Krishnamurthy K. Biochemistry, Peptide. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 29, 2022.

Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. doi:10.1152/japplphysiol.00945.2010

Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8

Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012;1270:37-44. doi:10.1111/j.1749-6632.2012.06717.x

Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. doi:10.1046/j.1523-1747.1999.00708.x

Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. Published 2020 Jan 30. doi:10.3390/molecules25030609

Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. doi:10.1023/a:1025493705728

Minami H, Morse EL, Adibi SA. Characteristics and mechanism of glutamine-dipeptide absorption in human intestine. Gastroenterology. 1992;103(1):3-11. doi:10.1016/0016-5085(92)91088-l

Kuznetsova TV, Schulga AA, Wulfson AN, et al. Producing human mechano growth factor (MGF) in Escherichia coli. Protein Expr Purif. 2008;58(1):70-77. doi:10.1016/j.pep.2007.10.023

Qin LL, Li XK, Xu J, et al. Mechano growth factor (MGF) promotes proliferation and inhibits differentiation of porcine satellite cells (PSCs) by down-regulation of key myogenic transcriptional factors. Mol Cell Biochem. 2012;370(1-2):221-230. doi:10.1007/s11010-012-1413-9

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