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How to Take Phentermine 37.5 for Best Results to Lose Weight: Taking Phentermine for Optimal Weight Loss - Expert Guide

This article focuses on the most effective ways to take Phentermine 37.5 for best results for weight loss and with safety in mind.

How to take Phentermine for best results?

Phentermine is a drug class appetite suppressant prescribed by doctors to obese patients to help them lose weight quickly. Due to the chemical and pharmaceutical nature of weight loss drugs like Phentermine 37.5 mg there are recommended usages and ways to for best results and safety.

This article focuses on the most effective ways to take Phentermine 37.5 for best results for weight loss and with safety in mind.

Best Phentermine OTC Brands

Here are the most effective and best selling phentermine diet pills available over the counter or online. The following three brands do not require a prescription and are available directly from the manufacturers website.

#1 - PhenQ


PhenQ is a premium appetite suppressant and fat burner that is available without prescription if purchased directly from the official website.

PhenQ has been on the market for nearly a decade and sets the bar in terms of before and after results, efficacy and safety. Consumers can expect rapid weight loss results with no side effects.

PhenQ is considered to be one of the best over the counter diet pills on the market. There is a long 60 money back guarantee free shipping is offered worldwide.

#2 - Phen24


Phen24 is another premier Phentermine pill that is slightly more complex than PhenQ - it comprises two sets of pills one for day and one for night.

Consumers can lose body weight consistently throughout the night and day and lower their Body Mass Index (BMI).

Phen24 works best with a Phentermine weight loss plan that involves a healthy diet intake and exercise regime.

#3 PhenGold


PhenGold is a newer Phentermine pill that is yet to establish itself in the market but offers a a natural alternative to prescribed phentermine weight loss drugs.

PhenGold can lead to healthy body weight reduction by suppressing appetite and burning body fat. It can be used in combination with other supplements so that you don't lose muscle mass.

Phentermine Reviews and Overview

Phentermine is an FDA approved drug and prescription weight loss medication. It is in a class of drugs called anorectics, which work by suppressing appetite. Phentermine stimulates the hypothalamus gland and affects certain neurotransmitters to decrease appetite. It is used for weight loss in obese patients when used short-term and combined with exercise, diet, and behavior change.

Some key points about Phentermine 37.5:

  • It is a controlled substance, classified as a Schedule IV controlled stimulant.

  • Phentermine pills are only approved for short term use (a few weeks). Long term use can lead to addiction and other side effects.

  • It works by acting as an appetite suppressant, stimulating the hypothalamus gland and affecting neurotransmitters in the brain to decrease appetite.

  • Phentermine 37.5 is usually prescribed along with lifestyle changes like diet and exercise for weight loss in obese patients.

  • Common side effects include increased blood pressure, dry mouth, insomnia, irritability and constipation.

  • It can interact with some medications like MAO inhibitors, so you need to tell your doctor about any medications or supplements you are taking.

  • It can cause withdrawal effects if stopped suddenly, so it needs to be tapered off under medical guidance.

  • The brand name for Phentermine is Adipex-P. It is also available in generic form.

  • It is classified as a Schedule IV controlled substance by the DEA due to risk of addiction and dependence.

  • You need a prescription from a licensed physician to obtain Phentermine.

How Does Phentermine Work?

Phentermine is a prescription appetite suppressant that helps patients lose weight. It works by affecting the central nervous system to stimulate the release of neurotransmitters in the brain that regulate appetite. In particular, it causes the release of norepinephrine, dopamine, and serotonin, which help reduce appetite and also boost mood.

When taken as prescribed by a doctor, Phentermine helps patients feel less hungry and more satisfied with smaller portions. This makes it easier to cut calories in order to eat fewer calories than the body burns. Over time, this calorie deficit leads to weight loss. Phentermine also provides patients with more energy and a metabolic boost, which can increase the number of calories burned during exercise or normal daily activity.

However, Phentermine is only approved for short-term weight loss, up to 12 weeks. Due to its stimulatory effects, the risks of side effects increase over time and with higher dosages. Potential side effects include increased heart rate, insomnia, and elevated blood pressure. Phentermine can also become addictive if used long-term or at high doses. For these reasons, it should only be used under the supervision of a doctor.

When combined with lifestyle changes like a balanced diet and regular exercise, Phentermine can be an effective tool for overweight or obese patients to kickstart their weight loss journey. But the effects are temporary unless permanent changes are made to eating and physical activity habits. Phentermine provides motivation and appetite suppression, but the patient still needs to put in the work to lose weight and keep it off. Overall, Phentermine should be used responsibly and as precisely and carefully as directed.


Phentermine provides motivation and appetite suppression, but the patient still needs to put in the work to lose weight and keep it off. Overall, Phentermine should be used responsibly and as precisely and carefully as directed.

What is the Correct Phentermine Dosage

Phentermine drugs are available in the following dosage

  • Oral Extended-Release Capsules
  • Prescribed Phentermine Disintegrating Tablets

The correct and usual adult dose of a Phentermine diet pill depends on several factors and should be determined by a doctor based on each individual patient. Some key things doctors consider when prescribing Phentermine include:

Body weight

Typically, the higher the weight, the higher the dosage may need to be to have an effect. Standard doses range from 15 to 37.5 mg per day.

Health conditions

Patients with conditions like high blood pressure or diabetes may need to start with a lower dose. The doctor may increase it gradually while monitoring side effects and health markers.

Risk of side effects

Lower doses around 15 to 30 mg are less likely to cause side effects like insomnia, increased heart rate, and elevated blood pressure. Higher doses should only be used when lower doses are not providing results and under close supervision of a doctor.

Previous use of Phentermine

For patients who have used Phentermine before for medical weight loss, a higher initial dose may be required to have the same appetite suppressing effects. But the maximum recommended dose is 37.5 mg to avoid dangerous side effects.


Length of treatment

Phentermine is only approved for up to 12 weeks. Doctors will typically start with a lower dose for the first few weeks, then increase if needed for the remaining time. The dose is rarely kept constant throughout the full 12 weeks.

Daily schedule

Doctors will consider a patient's daily routine when determining the timing of the dose. Phentermine should be taken in the morning to avoid insomnia at night. The extended release formulation may be better for those with variable schedules.

Most doctors will start Phentermine between 15 to 30 mg per day, then adjust the dose based on effectiveness and side effects for that individual patient and their unique attributes and circumstances. But the total dose should not exceed 37.5 mg per day, and the course of treatment is limited to 12 weeks to maintain safety.

Ways to Take Phentermine 37.5 To Lose Weight for Best Results

Phentermine 5 mg to 30 mg for most patients as an initial dose. This may need to be adjusted over the first few weeks.

Phentermine 30 mg is a common dosage for many average weight patients. It provides appetite suppression without severe side effects for most people.

Phentermine 37.5 mg is the maximum recommended daily dosage of Phentermine. Higher doses significantly increase the risks of side effects and adverse reactions. Only physicians should prescribe doses over 30 mg on a case by case basis under frequent monitoring.

Dosages most typically come in 15 mg, 30 mg, and 37.5 mg amounts. 7.5 mg and other doses are sometimes prescribed based on individual needs. It is best to take Phentermine on an empty stomach.


Take one dosage in the morning to avoid insomnia and sleep disruption. The extended-release formula may provide longer coverage for some patients with odd schedules.

Dosage adjustments should only be made under the guidance of your prescribing physician. Do not change or modify your dose without consulting your doctor first.

Most physicians will maintain patients on the lowest effective dosage of Phentermine based on individual requirements. Higher doses do not necessarily mean faster or greater weight loss. but they do mean more risk.

The typical course of Phentermine lasts for 12 weeks. However, doctors may take patients off it sooner if side effects become bothersome or if weight loss goals are met early. The drug is not meant for long term use due to risks.

When the patient completes 12 weeks of Phentermine or if the doctor takes them off it sooner, Phentermine can typically be repeated again after a break. But lifetime use should be limited due to risks and limitations on long term safety.

Phentermine in combination with diet and exercise is the most effective approach. Relying solely on Phentermine alone will not produce meaningful or sustainable weight loss results. Lifestyle changes are key.

How much weight can I lose taking phentermine 37.5

Most people lose around 5-10% of their starting body weight while on phentermine. However, weight loss results can vary significantly.

Losing around 1-2 lbs (0.5-1 kg) per week is considered a safe and reasonable goal. Losing weight too quickly on phentermine is not recommended.

In clinical studies, people lost around 3.6 to 6.4 lbs (1.6 to 2.9 kg) more weight on average compared to placebo over 12 weeks.

Higher doses of phentermine do not necessarily lead to more weight loss. The recommended dosage is usually 37.5 mg per day.

Possible Side Effects of Taking Phentermine

Some possible side effects of taking Phentermine include:

  • Insomnia and restlessness: Phentermine is a stimulant that can cause difficulty sleeping or restlessness in some people, especially if taken late in the day.

  • Increased heart rate: Phentermine may mildly elevate your heart rate and blood pressure due to its stimulatory effects. This can cause side effects such as palpitations, irregular heartbeat and chest pain in some patients.

  • Dry mouth: Phentermine can cause dry mouth due to reduced saliva production. This can lead to problems like difficulty swallowing, hoarseness, and sore throat. Drinking plenty of water can help reduce this side effect.

  • Dizziness or headache: Some people experience headaches, dizziness or a feeling of being lightheaded while taking Phentermine, typically when they first start taking it or after a dose increase. This usually improves over time, but can be a sign that the dosage needs adjustment.

  • Gastrointestinal issues: Problems like nausea, vomiting, constipation and diarrhea can occur in some patients. Taking medication with food and staying hydrated can minimize these side effects.

  • Impaired thinking: In rare cases, Phentermine may cause problems with concentration, memory loss, confusion and euphoria. This is more likely with high doses or if used longer than the recommended 12 weeks.

  • High blood pressure: Phentermine can cause a small elevation in blood pressure. While usually not significant, high blood pressure needs to be monitored and the dose may need adjustment or discontinuation if blood pressure becomes too high.

  • Addiction or dependence: Long term use or abuse of Phentermine can lead to addiction, dependence and other behavioral changes. This is why use is only approved for 12 weeks to minimize risks.

  • Withdrawal symptoms: Abruptly stopping Phentermine after long term use can lead to withdrawal symptoms such as extreme fatigue, depression, changes in appetite. Phentermine should be slowly tapered down under medical supervision.

How Long Does it take for Phentermine 37.5 mg to Work

Phentermine 37.5 mg, which is the maximum recommended dosage, works for most people within 1 to 2 weeks of starting the medication and diet/exercise plan. However, some factors that can influence how long it takes for Phentermine to start working include:

Individual factors: Things like metabolism, hormone levels, sleep quality, stress levels, etc. Some people may notice the effects sooner than others due to personal attributes. Staying well hydrated and rested can help your body respond better to the medication.

Diet and exercise: Phentermine alone will not cause significant weight loss. For the best and fastest results, Phentermine must be combined with lifestyle changes like healthy eating and daily exercise or physical activity. If you do not make changes to your calorie intake and activity levels, it may take longer for you to notice the effects.

Realistic expectations: Phentermine helps with appetite suppression and boosting metabolism, but weight loss still takes time. Losing 1 to 2 pounds per week is a safe and realistic rate of loss. Noticeable changes to your appetite and energy can happen quickly, but dropping a pants size can take a month or more. Be patient and consistent with your plan.

Prior use: Patients who have used Phentermine in the past may require a higher dosage (within the approved range) to achieve the same level of appetite suppression initially. But the maximum 37.5 mg dose should not be exceeded. High doses are not sustainable and only increase risks.

Switching from other diet drugs: Those switching from other prescription diet pills to Phentermine may experience less dramatic effects at first, especially if there was prior dependency or inadequate stopping of the other drug. It can take time for the body to adjust, so you should avoid comparing effectiveness against the other medication.

How to Take Phentermine 37.5 For Best Results FAQ

Can you take phentermine longer than 3 months?

No, Phentermine is only approved for short-term use of 12 weeks or less. Taking it longer increases risks of side effects and addiction.

How Can I Increase My Phentermine Effectiveness?

Follow the directions of your doctor. In addition, stay hydrated, get enough sleep, eat a balanced diet and exercise regularly. Making healthy lifestyle changes will boost the effectiveness of Phentermine.

How to Intensify Phentermine?

You should not intensify your Phentermine dosage without consulting your doctor. The maximum approved dose is 37.5 mg per day. Higher doses are unsafe and put you at risk of dangerous side effects. Focus on diet, exercise and lifestyle changes to boost your results.

How long do you take Phentermine Before You See Results?

Most people start to notice reduced appetite and increased energy within 1 to 2 weeks of starting Phentermine and making diet/exercise changes. However, substantial weight loss can take longer - up to 1-2 pounds per week is typical and healthy. Full results may take 3 to 4 weeks to become evident for some patients. Be consistent and patient, as there is no "quick fix".

What foods to eat while taking Phentermine 37.5 mg:

Focus on lean proteins like fish, eggs, beans; fresh veggies; whole grains; and healthy fats like nuts.

How to take Phentermine 37.5 for Best Results Summary

Take Phentermine exactly as prescribed by your doctor. The typical dosage is 37.5 mg once per day, about 1-2 hours after breakfast.

Stay hydrated by drinking plenty of water. Dehydration reduces the effectiveness.

Get 7-8 hours of sleep per night. Lack of sleep can compromise appetite suppressing effects.

Exercise for at least 30 minutes a day, 5 days a week. Exercise helps boost your metabolism and increases the amount of calories you burn.

Track your daily calorie and food intake to maintain a 500 to 1000 calorie deficit per day. Losing 1-2 pounds per week is the best approach for safe and sustainable weight loss with Phentermine.

Latest Clinical Studies and References up to September 2023


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