B Sai Praneeth's shock exit comes as no surprise as the star shuttler struggles for form in the badminton arena.
PV Sindhu, seeded seventh, made short work of China's Zhang Yi Man 21-12 21-10 in just 28 minutes in the women's singles second round clash.
PV Sindhu defeated Thailand's world no. 10 Pornpawee Chochuwong while Saina Nehwal lost to American Iris Wang in their first round matches at Malaysia Open.
India also registered twin wins in women's and mixed doubles competition on the opening day which saw B Sai Praneeth bow out.
Two-time Olympic medallist PV Sindhu suffered mid-game scare before beating Chinese He Bing Jiao 21-13, 17-21, 21-15 in the first round of Malaysia Masters.
While B Sai Praneeth went down to world number six Anthony Sinisuka Ginting, Sameer Verma lost to world number 8 Jonatan Christie.
The women’s doubles pair of Ashwini Ponnappa and N Sikki Reddy progressed to the second round while the mixed doubles pair of Tanisha Crasto and Ishaan Bhatnagar also won.
PV Sindhu lost 14-21 18-21 to Bing Jiao in the women's singles, while B Sai Praneeth lost to Hans-Kristian Solberg Vittinghus 16-21 19-21.
Lakshya Sen and B Sai Praneeth made first round exits. While Sen lost in three games, Praneeth was outplayed in two.
2018 bronze medallist India’s HS Prannoy has withdrawn from the Badminton Asia Championships 2022 after sustaining an injury during his Swiss Open final.