NMN is short for nicotinamide mononucleotide, a molecule that can be found naturally in all living organisms. At a molecular level, it is a ribo-nucleotide, a fundamental nucleic acid RNA building block. Structurally, NMN comprises a nicotinamide group, a ribose, and a phosphate group. It serves as the immediate precursor to the vital molecule nicotinamide adenine dinucleotide (NAD+), and it's known to be a crucial element in boosting NAD+ levels within cells.
NMN Supplement Benefits:
NMN supplement has gained popularity in recent years for its potential health benefits. Although NMN research is in its early stages, initial studies indicate promising results. Some of the possible benefits of best NMN supplements include:
- Increased NAD levels in the body
- Improved cognitive function, particularly in memory and attention tasks
- Improved muscle performance and physical endurance
- Better insulin sensitivity and glucose tolerance are crucial indicators of good metabolic health.
- Supporting healthy aging and potentially slows down the aging process
- Protecting against age-related diseases such as Alzheimer's and Parkinson's
- Supporting healthy DNA repair and cell regeneration
- Reducing inflammation in the body and supports a healthy immune system
- Promoting heart health and lowering the chances of developing heart disease.
- Providing more energy and overall well-being
Remember, it is always suggested to consult a doctor before starting a new NMN supplement regimen.
Does NMN Supplementation Work?
Animal studies, particularly in mice, suggest that taking NMN supplements may have various benefits, including reversing aging and enhancing cognitive health.
But does NMN supplementation really work in humans?
It is difficult to answer that question now as research on the effects of NMN supplementation in humans is still new, and few clinical trials have been published to demonstrate its clinical benefits.
One study researched the effects of taking 250 milligrams (mg) of NMN daily for ten weeks in postmenopausal women with pre-diabetes and overweight or obesity. Participants who consumed best NMN supplements showed improvements in insulin sensitivity and signaling. It should be noted that two of the study's authors hold patents related to NMN use.
A new study analyzed the impact of consuming NMN supplements on amateur runners while undergoing exercise training. The study involved 48 runners between the ages of 27 and 50 who were given oral NMN supplements of 300, 600, or 1200 mg daily for six weeks or a placebo. At the end of the sixth week, those who took NMN along with their exercise training exhibited improved aerobic capacity as compared to those who took the placebo.
Biggest Safety Concern When It Comes To NMN:
One of the major safety concerns is the prevalence of counterfeits and low-quality imitations. These products make similar claims to authentic ones but are sold at much lower prices. Unfortunately, many of them are not pure NMN and may contain other compounds. This raises safety concerns, especially if the manufacturer has yet to disclose the full list of ingredients used.
This is particularly true if a company manufactures its NMN in non-cGMP-certified facilities, with a more significant potential for impurities. It is important to remember that NMN is classified as a dietary supplement in the United States. As a result, it does not need to be proven effective and safe before being marketed.
Consumers should exercise caution when choosing which brand of NMN supplements to trust, as these products are subject to post-market enforcement by the Food and Drug Administration. Additionally, it may be helpful to understand the three standard methods used for manufacturing NMN:
This method is both labor-intensive and expensive, but it yields high-quality results and allows for precise control over the starting materials. However, none of the materials used are sourced from biological systems. Unfortunately, the process involves using environmentally harmful solvents, which can result in impurities and byproducts in the final product. Removing these impurities can be a difficult task.
This expensive preparation method produces high yield and purity and is considered a green option for NMN production.
This method has a low yield and is not suitable for commercial production. To ensure safety, choose transparent and independently approved brands.
Wonderfeel is an excellent example of a company that produces high-quality supplements. Their products are made in cGMP-certified facilities using enzymatic synthesis techniques. The starting material for their process is derived from a food-grade yeast called Kluyveromyces marxianus. The FDA considers this yeast safe and has gotten a "qualified presumption of safety" from the European Food Safety Authority.
Best NMN Supplements
Price per 1g NMN
Wonderfeel® Youngr™ NMN
LifeForce Peak NMN
The Four Best NMN Products that you must check out are:
Wonderfeel Youngr NMN
Wonderfeel Youngr NMN gives you a science-based and safe amount of daily NMN. It promotes increased energy, better skin elasticity, and clear cognitive function thanks to its novel formula and elevated NAD+ levels. It’s the only NMN formula patented for its performance. With emergent antioxidants and sirtuin activation, Youngr™ uses a multi-targeted approach to slow down biological aging at the cellular level.
Wonderfeel Youngr NMN is a potent and bioavailable formulation. Professor Andrew Salzman, an eminent Harvard MD, is the scientist behind this formula.
With Wonderfeel’s NMN supplements, you address the aging challenges from several angles with four active ingredients.
NMN (450mg): NAD+ augmentation, slower cellular aging, better cognitive activity, energy generation, healthy sleep cycles, and DNA stability.
Trans-resveratrol (50mg): Activates sirtuins and increases cell survival proteins at a lower dose, antioxidant and anti-inflammatory.
Ergothioneine (ERGO) (2mg): Accumulates to repair oxidative stress and cognitive and cardiovascular benefits.
Vitamin D3 (10mcg): Healthy bones, robust immune system, stem cell generation, diabetes prevention.
Hydroxytyrosol (Olea25) (40mg): Antioxidative and antitumor effects, healthy skin, eyes, and heart.
ERGO in Youngr NMN is derived from porcini and lion's mane medicinal mushrooms. Wonderfeel derived hydroxytyrosol, a potent polyphenol, from ripened and unprocessed olives.
Youngr NMN supplements have increased bioavailability, reaching the cells and tissues. The NMN formula from Youngr is designed to have enhanced bioavailability. It contains powerful antioxidants that protect NMN from oxidative stress as it travels through the body and reaches the tissues and cells. Additionally, the formula includes selected ingredients that activate sirtuins, which are enzymes that play a vital role in creating new mitochondria. The other benefits include:
- Increased NAD+ levels promote energy production and protect DNA stability while aging.
- Improved metabolism helps to mitigate age-related weight gain and adipose tissue formation.
- Muscle health through enhanced oxygen utilization elevates exercise stamina and aerobic capacity.
- According to clinical trials, we have improved sleep quality results from the circadian NAD+ molecule.
- Low risk of age-related diseases such as Alzheimer’s, Parkinson’s, dementia, and diabetes.
- Increased lifespan is one of the primary goals when taking NMN supplements, and it is the eventual outcome obtained with the above-mentioned health benefits.
There are no significant sideeffects following Youngr NMN administration. Wonderfeel’s supplement formula delivers 900 mg of daily NMN in two capsules. According to human and animal studies with similar doses, this is a safe and well-tolerated amount of daily NMN. People using NMN do not report toxicity or severe side effects.
Wonderfeel experts recommend taking two capsules in the morning with a source of healthy fat — natural yogurt, olive oil, or avocado. For optimal absorption and utilization in the body, dietary fat is required for resveratrol, hydroxytyrosol, and vitamin D3, as they are fat-soluble molecules.
One bottle contains 60 capsules. Wonderfeel offers a monthly subscription where you can save $15 for each order. You can also make a one-time purchase at the regular price.
1 Bottle: Regular price $88
1 Bottle: Price with monthly subscription $73
It’s crucial to note that, to align with expert recommendations and clinical study findings, one might need to consume more than the recommended serving of other brands. This distinction underscores Wonderfeel’s superior value proposition.
Signal is a cutting-edge cellular health supplement developed by Elysium Health, one of the leading companies in wellness. This product is designed to support cellular health and metabolic aging.
By optimizing cellular communication, Elysium Signal aims to improve overall cellular health, which can lead to tremendous health benefits, such as better sleep, increased energy, improved focus, and enhanced overall well-being.
While Elysium Health is dedicated to offering its customers clinically validated and rigorously tested products, the daily dose may not be sufficient for people looking for a real NMN experience.
Elysium’s NMN formula includes 250 mg of NMN per serving. The formula was developed by Leonard Guarente, Ph.D., Elysium’s founder, chief scientist, and renowned aging researcher and professor.
NMN (β-Nicotinamide Mononucleotide) (250mg)
SIRT3 Activation Complex (150mg)
Vegetable Magnesium Stearate
Sirtuin activation complex made with honokiol from magnolia tree bark and viniferin from grapevines to support healthy mitochondrial function.
- Elysium includes no added or artificial flavors.
- The supplement offers relatively reasonable prices and is affordable.
- One bottle of Elysium (30 capsules) doesn’t last you a month as the recommended dosage is two capsules a day.
- Despite its claims, Elysium may not be effective for everyone.
Take two capsules every morning, with or without food. Each bottle contains a 30-day supply. This product is only for healthy adults. Do not take it if you are pregnant or nursing. Consult with your physician before using.
One bottle contains 60 capsules, which is a 30-day supply. Elysium offers multiple subscription options where you can save up to 33%. You can also make a one-time purchase at the regular price.
1 Bottle: Regular price $60
1 Bottle each month: The price with a monthly subscription is $50
1 Bottle each month: Price with semi-annual subscription $270
1 Bottle each month: Price with annual subscription $480
LifeForce Peak NMN
Life Force presents its groundbreaking product – Peak NMN supplement- to unlock human potential and enhance vitality.
Peak NMN supplement results from meticulous research and development aimed at harnessing the potential of Nicotinamide Mononucleotide (NMN) to promote cellular health and energy production. Life Force recognizes that modern lifestyles often lead to oxidative stress, slowed metabolism, and overall energy decline. In response, the company sought to formulate a solution that addresses these challenges at the cellular level.
The manufacturing process of Peak NMN adheres to the highest standards of quality and safety. Produced in FDA-approved labs, the supplement undergoes rigorous testing at every stage, from raw material sourcing to final production.
Berberine HCL (66mg) offers a dynamic pathway to energize cellular metabolism.
NMN (Nicotinamide Mononucleotide) (375mg), this enzymatic co-factor, serves as a linchpin in cellular energy production and repair mechanisms
White Mulberry Extract (as Reducose) (200mg), abundant in compounds like Deoxynojirimycin (DNJ), White Mulberry extract extends its effects to blood sugar management.
Lithium Orotate (450mcg elemental Lithium) (10.5mg) by buffering neuronal cells against oxidative stress and supporting neurotransmitter balance compound, contributes to cognitive resilience.
Spermidine (5.7mg) is a biological marvel known for its influence on cellular autophagy.
- Most NMN generic supplements degrade in less than two months. Peak NMN™ includes only HPLC-tested NMN with 99% purity and 24 months’ stability.
- Supports NAD+ production, DNA repair, cellular energy, and stress regulation
- Includes Berberine and White Mulberry extract to support healthy blood sugar levels naturally
- Effects can vary based on lifestyle and genetics.
- Depending on the number of daily capsules, some people may experience mild to moderate side effects, such as nausea and jitteriness.
Start with one capsule daily and increase by one tablet every three days, as tolerated, to reach the recommended three capsules/day. It is best taken before lunch or dinner to help your body process carbohydrates.
Peak NMN is available for $90 per bottle, each containing 90 capsules. This carefully formulated supplement offers a comprehensive approach to revitalizing your life, supporting cellular health, and promoting overall well-being. With a commitment to customer satisfaction, Life Force offers a 90-day refund policy.
This lets you confidently experience Peak NMN's benefits, knowing that a guarantee backs your investment. If you're not completely satisfied within 90 days of purchase, you can avail of a refund, demonstrating Life Force's dedication to your journey towards enhanced vitality.
Elevant Prime Capsules are an epitome of scientific progress, encapsulating the essence of NMN-C – Nicotinamide Mononucleotide – a key player in the cellular repair. NMN-C is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme integral to numerous biological functions. The capsules are thoughtfully formulated to provide 125mg of NMN-C per serving, ensuring a potent dose to kickstart the cellular repair.
The profound effect on cellular function lies at the heart of Elevant Prime Capsules. By elevating NAD+ levels, these capsules empower cells with the energy required to execute their tasks optimally. The result is a rejuvenated sense of vitality and energy, fostering an internal environment conducive to overall wellness. Enhanced cellular repair and function translate to a more youthful outlook, making Elevant Prime an invaluable addition to the pursuit of healthy aging.
The capsules are meticulously crafted in FDA-approved laboratories that adhere to Good Manufacturing Practices (GMP) guidelines, ensuring the highest quality and safety standards. The commitment to using GRAS-certified ingredients underscores the brand's integrity and commitment to delivering a premium product.
β-Nicotinamide Mononucleotide (125mg)
Other ingredients: isomalt, hydroxypropyl-methilcellulose, microcrystalline cellulole, magnesium stearate
Elevant Prime capsules are not just a supplement but a transformative elixir that ushers in a new era of vitality, resilience, and well-being. This remarkable product brings prime benefits that elevate every facet of life, empowering individuals to thrive with renewed energy and youthful exuberance.
- Enhanced overall health and energy
- Cellular repair and longevity
- Promotes healthy aging
- Amplified vitality and strength
- Robust immunity
- Elevated lifestyle
The secret to Elevant Prime capsules' ability to deliver these prime benefits lies in the ingenious NMN-C® formula.
As this Elevant Prime review already stated, these capsules are backed by meticulous research and formulated with utmost care, and they have exhibited a commendable safety profile in numerous studies. Reported side effects are minimal and primarily restricted to occasional digestive discomfort, shared with most supplements.
Following the guided dosage recommendation, consult a healthcare professional before introducing any new supplement, especially if you are pre-diagnosed with a medical condition or taking medications. Always prioritize informed decision-making and personalized guidance when incorporating dietary supplements into your health routine.
Makers of this supplement suggest taking two capsules daily, with or without food. Before taking supplements, consult your doctor or pharmacist if you are pregnant, nursing, or have a chronic medical condition.
Elevant Prime capsules offer remarkable value at an accessible $59 per 60-capsule bottle. This generous supply provides a month's worth of revitalizing benefits. Additionally, the product is backed by a 30-day refund policy, which ensures your satisfaction and peace of mind.
In the rare event that you are not entirely content with your purchase, you can take advantage of the hassle-free refund policy within 30 days of purchase. This customer-centric approach reflects the brand's confidence in the efficacy of Elevant Prime capsules and their commitment to your well-being.
Natural food with NMN
One benefit of taking NMN is that it is already present in numerous fruits and vegetables that we may already consume. Although the levels of NMN in food may not be as high as those found in NMN supplements, consuming these foods regularly can help increase our intake.
Broccoli and Cabbage
Broccoli and cabbage are both rich sources of NMN, as well as other essential vitamins and minerals. In every 100g serving of broccoli and cabbage, there is a varying amount of NMN ranging from 0.25-1.12mg and 0.00-0.90mg, respectively. According to the Washington School of Medicine, the NMN present in broccoli can help combat muscle and skeletal degeneration, weight gain, and age-related effects. It may also enhance eyesight and insulin sensitivity.
Whether you consider a tomato a fruit or a vegetable, it offers numerous health benefits. In every 100 grams, tomatoes contain approximately 0.26-0.30 of NMN and are rich in essential vitamins like A, K, C, potassium, and folate. If you don't enjoy eating tomatoes alone, you can try fresh tomato juice or tomato cream soup as delicious alternatives.
Incorporating immature vegetables and baby greens into your diet can be an incredibly healthy choice. Edamame, for instance, is an example of an inexperienced vegetable that is similar to broccoli sprouts because it is an immature soybean. A single cup of edamame contains 0.37-1.68mg of daily NMN, providing 33% protein and 120% daily folate. The slow-aging benefits of edamame include protecting our immune systems, cognitive function, and cardiovascular health and acting as a potent antioxidant.
Other common foods that contain NMN are mushrooms, beef, and shrimp. These foods contain trace amounts of NMN, ranging from 0.01 to 0.42, which can still contribute to NMN intake.
Q: What are the criteria to choose the best NMN supplements?
Choosing the best NMN supplement can be daunting, especially with many companies claiming to be the best. However, there are one or two key points to remember when making your decision:
- Purity: The best NMN supplements use 98% purity NMN. This ensures that you're getting as much of the active ingredient as possible.
- Dosing: Most brands offer between 250mg - 750mg per serving, but higher doses are more effective.
- Quality: Look for supplements that keep their formula clean and avoid ingredients like artificial fillers and magnesium stearate. Vegan-friendly capsules are also a plus.
Q: Who should not be taking these supplements?
A nursing mother, pregnant woman, or an individual with chronic medical conditions like hypertension, diabetes, or heart disease should consult a doctor before purchasing or taking these supplements.
Q: How long do NMN supplements take to show results?
To answer the question, there is no clear-cut answer to how long it takes for NMN to start working, as it can vary from person to person. However, studies have shown that NMN supplements can increase NAD+ levels within a few weeks, with one study showing a measurable rise in blood NAD+ levels after 30 days.
Q: What are the NMN supplement's side effects?
Based on current scientific findings, NMN is predominantly viewed as safe for intake by a broad range of individuals. Comprehensive research underscores that even when consumed in generous amounts, NMN’s safety profile remains commendable.
Q: Is an NMN supplement safe to consume?
It's important to remember the safety of any supplement, including NMN, can be influenced by several factors, including dosage, frequency of use, age, gender, interactions with other medications or supplements, and underlying health conditions.
Q: When should you start consuming NMN supplements?
NAD levels start to decline as we age. This decline typically begins around our late 20s to early 30s and accelerates as we progress in age. Given this decline, many experts suggest that individuals might consider starting NMN supplementation in their 30s.
Q: What are the effective ways to increase your NMN naturally?
If you want to increase your NAD+ levels without supplements, there are several natural ways. Here are some options:
- High-intensity interval training (HIIT)
Studies have shown that HIIT can activate specific longevity genes that increase NAD+ levels. However, starting slowly and seeking advice from your physician and a trainer is essential to avoid adverse health implications.
Intermittent fasting has been shown to activate genes that can increase longevity at a cellular level. It's best to start with entry-level regimens like 18:6 fasting and seek medical advice before attempting more aggressive fasting methods.
- Heat and cold shock:
Your cells respond to stress by activating protective genes, which apply to heat and cold shock. However, it's essential to seek guidance from a professional to avoid causing harm.
NMN supplements are gaining popularity among people interested in anti-aging supplements due to their potential benefits. With the decline of NAD+ levels being linked to various age-related diseases, the expectation is that NMN, as the direct precursor to NAD+, can boost levels and extend longevity. The global anti-aging supplement market is projected to reach USD 8.4 billion by 2027, indicating consumers' growing interest in anti-aging supplements.
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