Advertisement
Wednesday, Sep 22, 2021
Outlook.com
Outlook.com

What Is Biological E Vaccine? Can It Be The Most ‘Affordable’ Jab? Know Here

Covid explained: Biological E is expected to produce 30 crore doses

What Is Biological E Vaccine? Can It Be The Most ‘Affordable’ Jab? Know Here
The vaccine candidates of Biological E, Zydus Cadila, Gennova, Bharat Biotech's nasal vaccine are in various stages of clinical trials. | Representational image
What Is Biological E Vaccine? Can It Be The Most ‘Affordable’ Jab? Know Here
outlookindia.com
2021-05-14T08:36:02+05:30

The Central Drugs Standard Control Organisation (CDSCO) has given permission to the Hyderabad-based pharmaceutical company Biological E Limited (BE) to start the Phase III clinical trial. In the second week of November 2020, Biological E had started the Phase I and II clinical trials of its Covid subunit vaccine candidate and has now completed them. The vaccine manufacturer will now conduct the Phase III trials of its candidate.

According to the Ministry of Health and Family Welfare, Biological E is expected to produce 30 crore doses, Zydus Cadila 5 crore, Serum Institute of India 20 crore doses of Novavax, and Bharat Biotech 10 crore doses of its nasal vaccine, while Genova will make available 6 crore doses and Sputnik V 15.6 crore doses.

Who are the Biological E’s Covid-19 vaccine candidates?

The vaccine candidates of Biological E, Zydus Cadila, Genova, Bharat Biotech's nasal vaccine are in various stages of clinical trials.

It includes an antigen developed by the Texas Children’s Hospital Center for Vaccine Development and in-licensed from BCM Ventures, Baylor College of Medicines integrated commercialization team, along with Dynavax Technologies Corporations advanced adjuvant CpG 1018TM.

The vaccine candidate consists of the Receptor Binding Domain of the Spike Protein of SARS-CoV-2 at a three-dose level adjuvanted with CpG 1018 plus alum. It uses recombinant-protein technology in which a harmless agent is used to stimulate an immune response in cells. During the trials, the vaccination schedule consisted of two doses for each study participant, administered via intramuscular injection 28 days apart.

The Phase III clinical study will be conducted in 15 sites across India:

According to reports, it will evaluate the immunogenicity and safety of Biological E’s SARS-CoV-2 Covid-19 vaccine. It will be done to access its protection against the disease in about 1,268 healthy subjects in the age range of 18 to 80 years. It is intended to be part of a larger global Phase III study.

Biological E Vaccine Rollout

India’s Biological E Ltd will soon start Phase III trials of its Covid-19 vaccine and plans to produce 75 million to 80 million doses a month from August, its managing director said on May 7, 2021. Government officials have said the vaccine could be rolled out in the country from August. Datla said Biological E. would apply for emergency use authorization (EUA) for the drug based on government advice. Production “from August but EUA depends on the government. Will follow their advice and directives," she told Reuters. “75-80 million doses a month from the time of launch."

Price of Bio E Vaccine

According to a Times Of India report, the pharma company has said its vaccine will be “one of the most affordable” options in India. Datla told the paper that while she is “not at liberty to share" details of pricing as it is still being worked out, “I can assure you it will be among the most affordable Covid-19 vaccines that you can get a hold of." She had further sought to assure that the company “will not take advantage of the situation”.

The company has also signed to produce 600 million doses of Johnson & Johnson’s single jab Covid-19 vaccine in India. Notably, Biological E has been promised funding for at least 1 billion doses by 2022-end from the US International Development Finance Corporation under the Quad initiative.

Advertisement

Outlook Newsletters

Advertisement

Read More from Outlook

Why PM Modi's US Visit Holds Key To India's Strategy On China, Afghanistan

Why PM Modi's US Visit Holds Key To India's Strategy On China, Afghanistan

Apart from in-person meetings with Joe Biden and Kamala Harris, PM Modi will address the UNGA and Quad summits and may share India's concerns on use of Afghanistan as a terror hub.

UK Puts Covishield Back Under Approved List: What It Means For Indian Travelers

UK Puts Covishield Back Under Approved List: What It Means For Indian Travelers

The updated advisory means that Indians fully vaccinated with Covishield will no longer be required to undergo compulsory 10-day self-isolation at home or declared location on entry to England.

Sunrisers Hyderabad Pacer T Natarajan Tests COVID-19 Positive

Sunrisers Hyderabad Pacer T Natarajan Tests COVID-19 Positive

The IPL, however, said that 'tonight's game between Sunrisers Hyderabad and Delhi Capitals will go ahead.'

First Jammu Bandh After Article 370 Abrogation Affects Normal Life

First Jammu Bandh After Article 370 Abrogation Affects Normal Life

Protests and rallies were taken out at various places of the region for the first time after the abrogation of Article 370.

Advertisement