Set an improbable victory target of 529, South Zone were all out for 234 in the first session of the fifth morning, having resumed the day at a precarious 154 for six.
Playing prominent roles in firing the West Zone to the big win were Yashasvi Jaiswal (265 in second innings), Sarfaraz Khan (127 in second innings) and the bowlers led by seasoned left-arm seamer Jaydev Unadkat.
West Zone put up a mammoth 585 for four in their second innings after conceding a 57-run first-innings lead to their opponents.
Prolific run-scorer Sarfaraz Khan recorded a fine, unbeaten century (127 off 178 balls) to continue West's charge after overnight double centurion Yashasvi Jaiswal was dismissed for 265 at the SNR College Cricket Ground.
The West bowlers did the job in the fourth innings with last Ranji Trophy's highest wicket-taker Shams Mulani picking up four wickets.
Batting for nearly five sessions, West left their opponents flattened, and the South Zone team did not quite recover from that. That was evident from their second innings batting as, with the exception of Rohan Kunnummal (93 off 100 balls), all batters failed to live up to the challenge.