Gurnoor Brar is set to make his ODI debut, earning a maiden cap after a string of impressive domestic performances.
India's batting unit is led by Rohit Sharma, Shubman Gill and KL Rahul, with Yashasvi Jaiswal and Shreyas Iyer adding depth.
The pace attack will be spearheaded by Arshdeep Singh, Prasidh Krishna and debutant Gurnoor Brar against Afghanistan.