Seeded players Iga Swiatek (1), Jessica Pegula (8), Garbine Muguruza (9), Danielle Collins (19), and Petra Kvitova (21) entered women's singles third round at US Open 2022. In men's singles, Carlos Alcaraz (3) and Jannik Sinner (11) registered straight-set wins in the second round. Day 4 action at Flushing Meadows also witnessed Venus and Serena Williams suffering a first-round defeat in women's doubles. In men's doubles, India's Rohan Bopanna and his Dutch partner Matwe Middelkoop made first round exit.