Benchmark indices remained on the backfoot for the second straight session on Tuesday, with the Sensex and Nifty declining almost 1 per cent each amid a sell-off in global markets.
Investors were also cautious ahead of the release of retail inflation and factory output data.
The 30-share BSE Sensex opened on a weak note and fell 508.62 points or 0.94 per cent to end at 53,886.61. During the day, it dropped 570.26 points or 1.04 per cent to 53,824.97.
The broader NSE Nifty declined 157.70 points or 0.97 per cent to settle at 16,058.30.
Among the Sensex constituents, Infosys, Nestle India, HCL Technologies, Hindustan Unilever, M&M and Kotak Mahindra Bank were the major laggards.
NTPC, Bharti Airtel and Bajaj Finance emerged as the gainers.
In Asia, markets in Shanghai, Tokyo, Seoul and Hong Kong ended in the red.
Stock markets in Europe were also trading lower in mid-session deals. The US markets had ended with losses on Monday.
Meanwhile, international oil benchmark Brent crude fell 2.37 per cent to $104.6 per barrel.
Foreign institutional investors remained net sellers on Monday as they offloaded shares worth Rs 170.51 crore, as per exchange data.