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Tesamorelin A-Z Guide: Benefits, Results, Dosage And More

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Tesamorelin A-Z Guide: Benefits, Results, Dosage And More

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analogue that stimulates the production and release of growth hormone (GH) from the pituitary gland.


Tesamorelin Peptide Review

Tesamorelin, an analogue of growth hormone-releasing hormone (GHRH), offers bodybuilders the best of both worlds. Besides stimulating rapid fat loss, this peptide accelerates recovery time and reduces the risk of injuries encountered during weightlifting.

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Just so you know, the above claims are backed by scientific research. Take, for instance, the one mentioning rapid fat loss. If Tesamorelin were unable to torch fat, the FDA wouldn’t have approved it as a treatment for HIV-associated lipodystrophy.

Lipodystrophy is a condition common in HIV-infected patients, where excess fat mounts up in some body organs, mainly the abdomen. That Tesamorelin could treat lipodystrophy should erase any doubt you may have about its ability to stimulate fat burning.

And how could it accelerate recovery time and lower the risk of injuries? By increasing the production and release of growth hormone (GH) in the body. Countless studies link high GH levels with a fast-track recovery time and low musculoskeletal injury risk.

What is Tesamorelin?

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analogue that stimulates the production and release of growth hormone (GH) from the pituitary gland. Tesamorelin also increases insulin-like growth factor-1 (IGF-1) levels in the body. [1]

Although its structure is similar to that of GHRH (both are 44 amino acids polypeptides), Tesamorelin’s N terminal has been modified. This has been done to improve its stability in the bloodstream, enabling Tesamorelin to exert its effects for extended periods. [2]

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In 2010, Tesamorelin was approved by the FDA as a treatment for HIV-associated lipodystrophy, a condition in which fat accumulates in some body parts while shrinking in others. Tesamorelin reduces excess abdominal fat in patients with lipodystrophy. [3]

Besides stimulating rapid fat loss, this growth hormone-releasing factor has been shown to lower triglyceride levels in HIV patients. Additionally, Tesamorelin improved cognitive function and verbal memory in patients with mild cognitive impairment. [4]

How Does Tesamorelin Work?

Tesamorelin works just like GHRH in the body. Upon entering the bloodstream, it binds to and activates the GHRH receptors on the surface of the pituitary, a pea-sized organ at the base of the brain. This triggers the production and release of GH in the body.

Besides increasing GH levels in the body, Tesamorelin also produces a dose-dependent increase in IGF-1 concentrations. IGF-1 is a hormone mainly produced by the liver. It promotes cellular growth and division, enhances protein synthesis, and regulates lipid metabolism.

Tesamorelin Benefits

Clinical trials show that Tesamorelin can offer several health-related benefits. This peptide can stimulate rapid fat loss, improve heart health, and enhance cognitive function.

Tesamorelin can also help make muscles bigger and stronger, prevent a liver disease called NAFLD, and increase the thickness of muscles. All these effects have been reported in human studies.

Here are the three proven benefits of this recombinant human growth hormone:

1) Shreds Stubborn Body Fat

Health experts tell us that abdominal fat is the hardest to lose because it has a higher amount of fat cells that show poor response to the fat-breakdown process. Fortunately, that is precisely the type of body fat that Tesamorelin targets and torches.

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Results from multiple studies show that Tesamorelin reduced abdominal fat accumulation to decrease waist circumference in humans. This indicates that this peptide can help you get a leaner physique with highly toned and well-defined abs. [5]

2) Increases Lean Muscle Mass

Clinical trials show that Tesamorelin could help you put on lean muscle mass.

This peptide significantly increased skeletal muscle mass, area, and density in a study involving HIV-infected patients. Significant reductions in belly fat were also reported alongside these positive changes in body composition. [6]

Another investigation showed that Tesamorelin improved body composition in patients with chronic obstructive pulmonary disease (a group of conditions that causes breathing-related issues). Specifically, this peptide increased the participants’ lean muscle mass. [7]

3) Improves Heart Health

Unlike the majority of synthetic peptides on the market, Tesamorelin doesn’t only help you get a leaner, muscular-looking physique.

This synthetic peptide can also help improve the functioning of your heart. It could do that by reducing the levels of triglycerides and C-reactive protein in your body.

Elevated levels of both these markers increase your risk of developing severe heart diseases. [8]

Another possible mechanism by which Tesamorelin could improve heart health is improving HDL (‘good’) cholesterol levels in your body. Finally, it could lower the thickness of carotid artery walls (increased thickness of these walls enhances your risk of cardiovascular disease) [9] [10]

Tesamorelin Results

Of all the synthetic peptides on the market right now, Tesamorelin is probably the best for achieving rapid fat loss, milligram per milligram.

Users who follow the dosage guidelines can expect speedy results, getting rid of stubborn belly fat that showed no signs of going anywhere for years.

Here are the fat loss effects of Tesamorelin as reported by users:

•    A 2.5% drop in body fat. Per a Reddit user who claims to have done an 8-week cycle of Tesamorelin (2mg/day for 5 days a week) [11]
Clinical studies have this to say about Tesamorelin’s fat-burning effects:

•    An 18% decrease in VAT. This was observed in participants who took one Tesamorelin injection/day for 26 weeks. [12]

•    A 14% decrease in VAT. This was experienced by participants from the above study who completed an additional 26-week cycle. [13]

In other words, users who take Tesamorelin for a cycle usually end up shredding off around 15-20 pounds of body fat. Don’t take our word for it, though. You can buy Tesamorelin here and try it.

Tesamorelin Dosage

Due to the various applications of Tesamorelin peptide, the recommended dosage guidelines vary depending on the specific purpose of its usage.

For anyone who wants to experience rapid fat loss, the most recommended dosage is 2mg daily, accompanied by adequate diet and exercise. 

Do not use more than one dose of this synthetic peptide in a 24-hour period. If you miss a dose and it’s already time for the next dose, skip the first to stick to your regular dosing schedule, and do not double dose.

Of course, be sure to use ample rubbing alcohol before injecting, throw away all used needles, and only inject into visceral adipose tissue, otherwise you may create scar tissue over time.

How To Take Tesamorelin

Tesamorelin is usually taken as a shot under your skin (subcutaneously), typically under the stomach’s skin or below the belly button, which is called a subcutaneous injection.

Keep in mind that Tesamorelin injection comes in powder form and needs to be reconstituted (mixed with a liquid) that comes with the injection. Unless you buy Tesamorelin from here , where it's already pre-made for you in a vial.

To inject Tesamorelin and begin your Tesamorelin therapy with this weight loss medication, draw your desired dosage into the syringe, push any air bubbles out, pinch a little bit of visceral adipose tissue (fat), and inject it subcutaneously below the layer of visceral fat.

Make sure to rotate the injection site each time you take a shot. This will make sure you don’t face any problems related to the injection, such as skin rashes. Also, make sure to follow the patient instructions (preparation and usage instructions) that the injection will come with.

Where to Buy Tesamorelin?

Paradigm Peptides is the best place to buy Tesamorelin online.

Paradigm Peptides is your premium peptide therapies headquarter. We provide reference materials with every product we sell. Our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. 

We have a flat shipping rate of $10 for all US-based orders. You can pay for your purchase through various methods, including credit cards, Zelle, CashApp, and Venmo. We also offer shipping insurance for as low as $2.50.

Side Effects

Individuals with a history of pituitary gland tumor, acute respiratory failure, and glucose intolerance shouldn’t use Tesamorelin.
Common side effects include:
•    Diarrhea
•    Redness/itching/rashness
•    Muscle aches
•    Vomiting

Immediately tell your doctor if you experience severe adverse effects, including allergic reaction, chest tightness, or heart palpitations. In case of an overdose, consult your local poison control center with a record of medical and lab appointments.

Typically, only HIV infected individuals going through antiretroviral therapy will experience some of the side effects of Tesamorelin. If you're on other medicines or other drugs that could conflict with this compound, be sure to tell your doctor.


Tesamorelin is a synthetic analog of GHRH that can help you get rid of stubborn body fat, put on lean muscle mass, and improve heart health. This makes it a must-have for anyone looking to develop an athletic and more muscular physique. 

This growth hormone releasing factor Tesamorelin is an amazing over the counter solution to anyone who wants to significantly affect their pituitary hormones, who has an adrenal gland disorder, kidney disease, peripheral edema, or human immunodeficiency virus.

By using Tesamorelin to increase growth hormone releasing factor and insulin growth factor, as well as other pituitary hormones, users will note an improved metabolic profile, improve cognitive function, and overall weight loss benefits.


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