Outlook Spotlight

Cardarine SARM GW 501516 Results, Cycle, Dosage For Cutting Fat, Buy Legal Cardarine 2023

In this article, we have provided an honest outline of GW-501516 and the things that it may do, good and bad.

Advertisement

Cardarine SARM GW 501516
info_icon

If you are looking at the fat burning results of Cardarine GW 501516 and thinking of using it in your bodybuilding cutting cycle for 2023, read our Cardarine SARM guide first. We explain the correct GW-510516 dosage, how to cycle, what PCT and what the possible fat loss results can be. We will also tell you where to buy legal Cardarine SARMs in the United States, Canada and Australia.

Best Legal Cardarine SARM to Use for Cutting Cycles

C-Dine 501516 from CrazyBulk is arguably the best legal Cardarine brand to use for cutting cycles for 2023. It is a hybrid SARM that is both safe to use and legal to buy (and use for bodybuilding).

Advertisement

info_icon
C-Dine 501516

If you want to maximize your fat burning on cutting cycles a legal and safe alternative such as C-Dine 501516 is an excellent choice for 2023

C-Dine can also be combined with other legal SARMs and cutting supplements to create a cutting stack. A cutting stack can amplify your fat burning results exponentially while preserving lean muscle mass.

What is Cardarine

Also known as GW 501516 and Endurobol, Cardarine is an experimental drug that's popular in bodybuilding, where it's predominantly used as a fat burner during cutting cycles.

Advertisement

Cardarine GW 501516 isn't only popular with bodybuilders. Some athletes use it as a performance-enhancing drug (PED) and it may have more value in this area.

There is a common misconception that GW 501516 is a SARM (selective androgen receptor modulator). It's not but a lot of people presume that it is because it's such a common addition to SARMs cutting stacks. Either way it is a highly effective fat loss agent. Cardarine GW501516 is arguably one of the best SARMs to buy and use in bodybuilding.

Cardarine Specifications

GW501516 is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s.

Molar mass: 453.498 g/mol

Formula: C21H18F3NO3S2

ChemSpider ID: 7979723

ChEMBL Id: 38943

Cardarine GW 501516 is a peroxisome proliferator-activated receptor (PPAR) agonist that acts on muscle cells, causing increases in energy expenditure and increasing fatty acid oxidation.

SARMs do not do this. They act on androgen receptors in the muscles, causing improvements in protein synthesis and muscle growth.

It's pointless looking at SARMs in any more detail, though. Doing so would add little or no value to this article. The takeaway point we wish to get across is SARMs and PPAR agonists are similar but different agents.

Cardarine GW 501516 History, Original Intention

Advertisement

GW 501516 was created in the early 1990s. It's the result of a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline.

The companies were initially hoping GW-501516 could be developed into a viable treatment for hyperlipidemia (elevated fats in the blood). They later discovered the drug's potential value as a treatment for diabetes, obesity, and cardiovascular disease.

Ligand Pharmaceuticals and GlaxoSmithKline eventually decided to concentrate on the new drug's potential value as a treatment for metabolic and cardiovascular diseases and it entered the clinical development stage. They abandoned the project in 2007.

Pharmaceutical companies are always trying to develop new drugs, most of which prove to be ineffective and/or dangerous. When Ligand Pharmaceuticals and GlaxoSmithKline dropped GW 501516, that should have been it⸺game over.

Advertisement

However, some of the animal-based studies suggested GW-501516 had value as a drug for enhancing physical performance. [1] Others highlighted its abilities as a fat burner and to lose weight. [2]

As is often the case in these types of situations, bodybuilders and other athletes learned of the drug and the things it appeared to be capable of doing and began obtaining it via illegal sources.

These days, many bodybuilders use GW-501516 for cutting. However, even though most of the people who use GW-501516 for bodybuilding or sports enhancement are aware of it, they continue to ignore a crucial fact:

Advertisement

Ligand Pharmaceuticals and GlaxoSmithKline stopped trying to develop Cardarine GW 501516 after all the rodents in one of their clinical trials developed fast-acting cancerous tumors in many of their organs.

If this was such a big red flag for experts in the pharmaceutical industry, how can bodybuilders think they know better?

We have said it before and we will say it again: People using GW-501516 are turning themselves into guinea pigs.

Cardarine GW 501516 Bodybuilding Uses

In bodybuilding, Cardarine GW 501516 is mainly used during cutting cycles to reduce body fat percentage. It's not unheard of for bodybuilders to add it to their bulking stacks but enhancing muscle growth is not an area where this drug is deemed to excel.

Advertisement

However, regardless of whether you are using Cardarine GW 501516 for cutting or bulking, its performance-boosting capabilities should help support better workouts.

Unless you are a bodybuilding newbie, you should be aware that most people who are serious about the sport alternate between two cycles⸺bulking and cutting.

During bulking cycles, the main focus is increasing muscle mass. Typical bulking diets are high in calories so bodybuilders who are bulking often gain fat as well as muscle.

Cutting cycles focus on fat loss. As with weight loss diets, they require a low-calorie intake. This is necessary to cause the body to begin burning body fat to get the extra energy it needs.

Advertisement

Unfortunately, the body may also burn a small percentage of muscle tissue for energy too. This is counterproductive. That's why some bodybuilders use steroids, SARMs, and/or other fat-burning drugs, such as Cardarine GW 501516.

GW-501516 helps the body to start using its fat deposits for energy by inhibiting the formation of fatty acid chains. By doing this, the drug stops the body from storing fat.

It also encourages the body to use its stored fat more efficiently than it would in normal starvation mode. That's the theory, anyway.

Cardarine GW 501516 may also protect existing muscle mass, preventing the breakdown of muscle tissue that would normally happen during starvation mode.

Advertisement

The drug also appears to enhance oxygen usage within the muscles' slow twitch fibers. By doing this, it may boost physical performance and speed up post-workout recovery.

Finally, by binding to PPAR agonist receptors, Cardarine GW 501516 should provide a helpful energy boost.

Research certainly shows the drug can enhance running capabilities in mice. [1]. But will it do the same for humans?

How Does Cardarine Work for Cutting Body Fat?

Cardarine GW 501516, or GW-501516, is a selective androgen receptor modulator that helps to reduce body fat.

It works by targeting skeletal muscle cells, promoting the production of amp activated protein kinase. This enzyme increases the rate of fatty acid oxidation which leads to an increase in energy expenditure.

Advertisement

As a result, the body tissue burning fat is enhanced, leading to the reduction in overall body fat content. In addition to reducing excess fat, it also helps to reduce metabolic syndrome including type 2 diabetes, obesity, and dyslipidemia.

Studies have found that GW 501516 significantly improves lipid profiles in mice by increasing HDL cholesterol levels while decreasing triglycerides and LDL cholesterol levels.

Cardarine GW 501516 Dosage

GW 501516 never left the development stage and, because it has never been put through many clinical trials involving humans, a safe and effective dose was never established.

However, many bodybuilders take Cardarine GW 501516 in doses of 10 mg per day, split over two doses. The half-life of the drug is 16-24 hours so one dose per day isn't going to "cut" it.

Advertisement

Some bodybuilders use 20 mg of Cardarine GW 501516 per day. In theory, doing so may improve the benefits. It will certainly increase the risk of side effects.

It's important to remember the doses bodybuilders use are based on locker-room talk or information published online, not scientific knowledge.

This, in turn, is based on the results bodybuilders have obtained from Cardarine GW 501516 through trial and error experience.

Although using GW-501516 on its own is not unheard of, most bodybuilders stack it with other bodybuilding drugs, such as anabolic steroids and SARMs.

Again, although this may increase the benefits, it will also increase the risks.

Advertisement

However, many steroids and SARMs cause unfavorable changes in cholesterol. GW-501516 does not.

In fact, the results of a small, human-based study, suggest it influences blood lipoproteins for the better. [3].

So, when bodybuilders add GW-501516 to their bulking or cutting stacks, it could be argued it may help reduce the unfavorable changes in blood lipids, the other drugs in the stack may potentially cause.

GW-501516 stacks well with most other bodybuilding supplements, but LGD-4033 (Ligandrol) and MK-677 (Ibutamoren) are among the most popular cutting stack partners that burn fat.

Cardarine is an excellent cutting agent as it preserves lean mass and muscle tissues.

Advertisement

Cardarine GW 501516 Cycle and PCT

As with SARMs, steroids, and similar drugs; it's necessary to use GW-501516 in cycles. These should never exceed 12 weeks. It's advisable to follow each cycle with a break of four to six weeks.

Cardarine GW 501516 does not take over the role of testosterone. Therefore, it does not cause any suppression of natural testosterone. So, when you are using this particular bodybuilding drug, there is no need to follow your cycles with a PCT (post-cycle therapy.)

Unfortunately, GW-501516 is often stacked with drugs that do suppress testosterone. The drug cannot compensate for their ability to do this.

Advertisement

So, depending on the choice of stacking partner, you may still need to do a PCT.

However, some bodybuilders include GW-501516 in their PCTs instead of their cutting cycles.

In theory, doing so may help prevent post-cycle fat rebound.

"Fat rebound" is a popular term that describes the rapid weight gain many people experience after finishing successful weight loss diets or cutting cycles. [4]

Many bodybuilders have problems with fat rebound so it's easy to understand why using GW-501516 post-cycle is such an attractive option.

Some bodybuilders state taking the drug post-cycle also helps them to avoid reductions in energy levels and training capacity.

Advertisement

Cardarine GW 501516 Side Effects

The potential side effects should be a major concern to anyone who is considering using GW-501516 for bodybuilding or weight loss. Let's not forget the mice and rats used in one study rapidly developed cancerous tumors. [5]

Regardless of the potential dangers, many athletes continue to obtain GW-501516 via the black market. The World Anti-Doping Agency (WADA) is aware of this because so many athletes have been caught out by testing.

WADA is so concerned about the potential dangers of using the drug that, in March 2013, it took the rare step of issuing a health warning that points out the reasons why the GW-501516 was withdrawn from research. [6]

Advertisement

Athletes regularly test positive for performance-enhancing drugs. When they do, the main thing WADA normally does is issue competition bans.

The fact that it felt it was necessary to single out GW-501516 as being dangerous enough to require this type of special treatment should give anyone planning on using it extra pause for thought.

Bodybuilders who use GW-501516 often share their experiences on forums. Side effects are one of the issues that are often discussed.

Here are some of the side effects bodybuilders report:

  • Fatigue
  • Headaches
  • Dizziness
  • Joint pain
  • Stomach aches
  • Diarrhea
  • Irregular heartbeat

Is Cardarine GW 501516 Legal to Buy?

GW-501516 is a black-market drug. By even buying it in the first place, people who use it are breaking the law. In many countries, even having the drug in your possession is a crime.

Advertisement

It's debatable if law agencies would decide to prosecute but WADA takes a very dim view of people who test positive for GW-501516. So, although it may be possible to avoid bad experiences with jail food, it's next to impossible to avoid competition bans.

Where to Buy Cardarine for Cutting Cycles and Bodybuilding?

info_icon
C-Dine 501516

Cardarine GW 501516 Cutting Cycle Results

It's very difficult to get an idea of the kind of bodybuilding results people should expect from GW-501516 because athletes seldom run it alone. It's more common to use it in stacks. Especially ones that are primarily made up of SARMs.

Advertisement

When you are using a cocktail of drugs, it's hard to pin down which one is producing certain benefits or side effects.

It's a challenging task but, even when you do find reports by people who have run GW-501516 on its own, opinions differ a lot.

For instance, some bodybuilders praise the drug's abilities as an energy provider but say it works poorly as a fat burner. Others say that, as an energy booster, GW-501516 was a disappointment. That's surprising if you think back to that study involving the running mice. However, the drug went out of development before it was tested on running people.

Advertisement

Just because certain drugs offer certain benefits to mice, there are no guarantees they will do the same for people. We can only hope that extends to any harm they may have caused mice.

One bodybuilding forum user claims GW-501516 made him feel like he could go on working out indefinitely.

When you read the GW-501516 results posted on bodybuilding forums, there is very little mention of improvements in fat burning. That makes it all the more unusual that it's such a common inclusion in SARMs cutting stacks.

Cardarine GW 501516 Summary and Conclusion

Based on the results of a limited number of animal experiments, GW-501516 has become a popular option with bodybuilders who are cutting. Strangely, the results many bodybuilders report fail to suggest it is an effective fat burner for humans.

Advertisement

By and large, the drug appears to have more to offer as a performance enhancer. However, what was once an exciting new prospective treatment for obesity and cardiovascular disease was later linked to risks of cancer and quickly became a black market special. It retains that status to this day.

In this article, we have provided an honest outline of GW-501516 and the things that it may do, good and bad.

It's not our place to warn anyone not to use it. Nor do we offer any encouragement to people who are thinking of doing so.

However, by providing the pros and cons, we hope we have been able to help you decide if using or buying Cardarine GW 501516 is an acceptable risk.

Advertisement

The above is a sponsored post, the views expressed are those of the sponsor/author and do not represent the stand and views of Outlook Editorial.

Advertisement