Best NMN Supplements To Buy 2023, Top 5 Capsules

If you’re familiar with NMN (nicotinamide mononucleotide) you may already know that this naturally occurring compound in the body plays a crucial role in energy production and DNA repair. NMN is a precursor to NAD (nicotinamide adenine dinucleotide), an essential coenzyme that helps regulate cellular metabolism and communication. In other words, it’s the key to cellular energy. As we age, however, our NAD levels naturally decline, which can trigger cascading effects in terms of health issues and accelerated aging. By the time we reach 50, our NAD levels are approximately half of what they were at the age of 20, with this decline starting as early as our 30s. Enter NMN supplements, which are designed to increase NAD levels and have become increasingly popular in recent years due to their potential benefits for both longevity and anti-aging.

In this article, we’re sharing the 5 best NMN supplements on the market in 2023. It’s a list we’ve compiled based on specific criteria, including purity, efficacy, and brand reputation. We’re also taking a close look at the science behind NMN, as well as its potential benefits and side effects, to give you a comprehensive understanding of this powerful compound’s health potential.

A Quick Look at Best NMN Supplements in 2023

5 Best NMN Supplements in 2023

1. Wonderfeel NMN 
   Best Overall NMN Supplement of 2023

• Price per 1g NMN: $2.70
• NMN per serving: 900mg
• Other ingredients: Ergothioneine, hydroxytyrosol, resveratrol, vitamin D3

Wonderfeel Youngr™ is a patented NMN supplement that includes a selection of handpicked antioxidants and sirtuin activators—ergothioneine, hydroxytyrosol, resveratrol, and vitamin D3. This combination of ingredients is designed to work synergistically to support healthy aging by increasing NAD levels, reducing inflammation, and protecting against oxidative stress.

Professor Andrew Salzman MD, a leading biomedical expert, developed the Wonderfeel NMN formula in association with the Wonderfeel team. Together, they referenced the largest and most comprehensive NMN clinical trial to calculate the most appropriate and effective dose of NMN in the Youngr™ formula. In addition to 900 mg of NMN, a daily serving includes:

• 4 mg ergothioneine: Also known as the “longevity vitamin,” ergo is an adaptive antioxidant found in certain mushrooms. Continued scientific evidence suggests ergo has tremendous cognitive benefits and prevents the brain from aging. In this formula ergo also functions as a sirtuin activator.
• 50 mg of olive fruit extract (40% hydroxytyrosol: This potent polyphenol has anti-inflammatory and antitumor properties, along with metabolic benefits.
• 100 mg of resveratrol: Working jointly with NMN as a sirtuin activator, this polyphenol boosts mitochondrial activity and allays metabolic disease. Studies have shown that resveratrol at a lower dose acts as an anti-apoptotic agent, thus increasing cell survival proteins.
• 20 mcg of Vitamin D3: D3 plays a big part in your body: making insulin, boosting immunity, and helping your gut's stem cells.

Wonderfeel Youngr has received outstanding reviews from customers who report improved energy, mental clarity, and overall well-being.

It’s an impressively high-quality NMN supplement with an efficacious blend of clinically studied ingredients that work together to maximize benefits. That makes it a worthwhile investment for individuals looking to support healthy aging and improve their overall well-being. Equally important is the company’s commitment to exceeding standards throughout the entire manufacturing process. Wonderfeel NMN is made at cGMP facilities via a pure enzymatic process to ensure the purest, safest, and most effective supplement possible.

Wonderfeel Youngr NMN is available as a one-time purchase or with a subscription to save $15.

Shop now at Wonderfeel®.

2. Elysium Signal
   Best Low-Dose NMN Supplement of 2023

• Price per 1g NMN: $5.33
• NMN per serving: 250mg
• Other ingredients: Honokiol, viniferin

Signal is a cutting-edge cellular health supplement developed by Elysium Health, one of the leading companies in wellness. This product is designed to support cellular health and metabolic aging.

Elysium’s NMN formula includes 250 mg of NMN per serving, plus a sirtuin activation complex made with honokiol from magnolia tree bark and viniferin from grapevines to support healthy mitochondrial function. The formula was developed by Leonard Guarente, Ph.D., Elysium’s founder, chief scientist, and renowned aging researcher and professor.

By optimizing cellular communication, Elysium Signal aims to improve overall cellular health, which in turn can lead to numerous health benefits, such as increased energy, better sleep, improved focus, and enhanced overall well-being.

While Elysium Health is dedicated to offering clinically validated and rigorously tested products to its customers, the daily dose may not be sufficient for people looking for a real NMN experience.

3. Lifeforce Peak NMN
   Best NMN Supplement for Fans of Berberine

• Price per 1g NMN: $6.22
• NMN per serving: 375mg
• Other ingredients: Berberine HCl, white mulberry extract, lithium orotate, and spermidine

Peak NMN is developed by Lifeforce to support high-sensitivity c-reactive protein, comprehensive metabolic panel, glucose, hemoglobin A1c, and total testosterone. It is one of the best NMN supplements for berberine lovers.

Berberine is the highest-dose ingredient in this formula. While it can help regulate insulin sensitivity and lower cholesterol levels, berberine can also interfere with the absorption of other ingredients. It’s important to consult your physician before taking it.

A serving size is three capsules, which nets 375 mg of NMN. Lifeforce recommends taking 1-3 capsules in the afternoon or evening before a meal for the greatest efficacy.

4. Elevant Prime
   Best NMN Supplement for Immune Support

• Price per 1g NMN: $6.69
• NMN per serving: 125mg

Elevant Prime NMN-C is a unique nutritional supplement developed by Elevant to promote cellular health and healthy aging, increase energy levels, and fuel a healthy and active lifestyle.

Elevant uses NMN-C in its formula. According to the company, it’s a high-quality form of NMN. Elevant says that in the first two weeks, NMN-C recharges your cellular energy. After four weeks, the body is optimized to more effectively defend against infection and inflammation.

Elevant places a strong emphasis on the quality, safety, and effectiveness of its products. The company maintains stringent quality control standards, and Elevant Prime NMN-C undergoes thorough third-party testing to ensure the product's purity, potency, and overall quality.

5. Awakened Alchemy Revitacell
   Best NMN Supplement with CoQ10

• Price per 1g NMN: $14.62
• NMN per serving: 250mg
• Other ingredients: Shilajit, ubiquinol, grape vine, olive leaf extract, and ergothioneine

RevitaCell is a premium NMN supplement developed by Awakened Alchemy, a company specializing in high-quality, natural health products. The supplement is designed to support cellular health, promote longevity, and improve overall well-being.

RevitaCell's primary ingredients work synergistically to target cellular health, increase NAD levels, and support various aspects of well-being. Pterostilbene and resveratrol are natural compounds known for their antioxidant and anti-aging properties, while CoQ10 plays a significant role in energy generation and overall cellular function. Like Wonderfeel, RevitaCell uses Ergo, one of our favorite ingredients for longevity.

Awakened Alchemy is committed to providing high-quality, effective, and safe products to its customers. By offering innovative, science-backed supplements like RevitaCell, Awakened Alchemy aims to empower individuals to take control of their health and well-being, support healthy aging, and enhance their overall quality of life.

How to Choose the Best NMN Supplements

It’s important for consumers to shop wisely for NMN supplements. That means keeping the following considerations in mind:

1. Quality and purity of ingredients: Always opt for products that have been tested for purity and potency by third-party labs. Scan the label, and avoid brands that have an excessive amount of ingredients. The best brands keep their formula clean with no extraneous fillers.
2. Dosage and concentration: Look for NMN supplements with an effective dose. Most brands have between 250mg-750mg per serving. Current research suggests that higher dosing—up to 900mg per serving—is more effective.
3. Brand reputation and customer reviews: Choose products from reputable brands that have positive customer reviews and a good reputation in the market.
4. Price and value for money: Avoid NMN supplements that are excessively priced or really inexpensive. Supplement quality depends on the actual amounts of active ingredients, and products that are priced significantly higher than competitors may also contain fillers to add bulk (and drive up prices). Those that are priced much lower than competitors likely contain low-quality ingredients or follow inferior manufacturing methods.
5. Manufacturing process and certifications: Choose products that are manufactured using good manufacturing practices (GMP) and have been certified by regulatory bodies such as the FDA.

Current NMN Research

Numerous studies have been conducted to investigate the potential benefits of NMN. One study with 31 healthy adult men and women aged 20–65 years found that NMN is safe and well-tolerated in healthy adult men and women with an oral dose of 1250 mg once daily. Another well-conducted study according to Professor Salzman, the chief formulator of Wonderfeel NMN, indicates that a combination of NMN and exercise improves aerobic capacity and muscle oxygen utilization compared to exercise alone in 600mg and 1200mg groups. NMN increases the aerobic capacity of humans during exercise training, and the improvement is likely the result of enhanced O2 utilization of the skeletal muscle. Additionally, this study conducted with 108 healthy adults over 65 years old suggests the potential of NMN in preventing loss of physical performance and improving fatigue in older adults.

What Does NMN Do?

NMN plays a crucial role in the body's energy production and DNA repair processes. As a precursor to NAD, NMN is essential for maintaining healthy cellular metabolism and communication. By increasing NMN levels in the body, NAD production can also be boosted, leading to potential benefits such as improved cognitive function, increased energy levels, and enhanced muscle performance.

Additionally, NMN has been studied for its potential anti-aging effects, as it may help protect against age-related decline in cellular function and oxidative stress. NMN's ability to support cellular health and energy production makes it a promising supplement for improving overall health and potentially slowing the aging process.

NMN Supplement Benefits

NMN supplement has gained popularity in recent years for its potential health benefits. While research on NMN is still in its early stages, initial studies have shown promising results. Some of the potential benefits of NMN supplements include:

• Increased NAD levels in the body
• Improved cognitive function, particularly in memory and attention tasks
• Improved muscle performance and physical endurance
• Improved insulin sensitivity and glucose tolerance, which are important markers of metabolic health
• Supporting healthy aging and potentially slows down the aging process
• Protecting against age-related diseases such as Alzheimer's and Parkinson's
• Supporting healthy DNA repair and cell regeneration
• Reducing inflammation in the body and supports a healthy immune system
• Supporting cardiovascular health and reduces the risk of heart disease
• Providing more energy and overall well-being

Remember, it's always a good idea to speak with a healthcare professional before starting any new supplement regimen.

NMN Safety & Side Effects

To date, no studies have found any significant health risks or negative side effects associated with NMN supplementation. A 2022 trial–the largest NMN study to date–found no signs of toxicity at dosing amounts of 300, 600, and 900 mg per day. That supports previous research that found little evidence of side effects of NMN supplementation.

While more research is needed to fully understand the long-term safety and efficacy of NMN supplementation, the available evidence to date suggests that it is a safe and well-tolerated supplement with no significant health risks or negative side effects reported.

Do NMN Supplements Cause Cancer?

Scientists have shown that NAD supplementation can help fight tumors by boosting the efficacy of these immune cells. Research is clear that NAD provides energy to cells and increases cellular activity. Keep in mind that cancer cells require a lot of energy to grow and divide, hence they demand more NAD. Therefore, NAD has a complex relationship with cancer. However, there is no evidence to suggest that NAD supplements cause cancer in healthy cells.

Since NAD precursors like NMN and NR are designed to increase overall cellular activity, those who are currently diagnosed with cancer should avoid these supplements.

How Much NMN Should I Take?

NMN dosage is an important consideration. The latest clinical trial examined the effects of NMN supplementation on 80 participants who were divided into four groups: placebo, 300 mg, 600 mg, and 900 mg. The trial evaluated three markers: NAD levels in the blood, performance in a six-minute walking endurance test, and results from a self-completed SF-36 questionnaire measuring overall health. The trial showed that those receiving 900mg NMN performed better than those on lower doses.

David Sinclair, a renowned Harvard Medical School professor and one of the leading experts on aging research, has been a vocal advocate of NMN and its potential benefits for healthy aging. He has publically shared that he takes a daily dose of 1 gram (1,000mg) of NMN, split into two doses of 500mg each. Sinclair has based his NMN dosage recommendation on his own research and personal experience, as well as findings from preclinical studies on mice.

When Does NMN Start Working?

The length of time it takes for NMN to begin working can vary depending on the individual and their specific health needs. While some people may experience benefits such as increased energy levels or improved cognitive function relatively quickly, that’s not the case for everyone. Remember, NMN supplements are designed to increase NAD levels in the body, which can take time.

In general, it is advised that people take NMN consistently for at least three months before expecting to see significant results. However, it is important to note that individual results may vary, and it may take longer for some people to experience the full benefits of NMN supplementation.

Is There A Best Time to Take NMN Supplements?

There is currently limited research on the timing and frequency of NMN supplementation. However, some studies have suggested that taking NMN earlier in the day may be more beneficial as it aligns with the body's natural circadian rhythm.

It is generally recommended to take NMN supplements with a healthy fat source to improve absorption and minimize any potential digestive discomfort. It is also important to follow the recommended dosage guidelines provided by the specific supplement brand, as dosages may vary depending on the formulation.

Can NMN Supplements Reverse Aging?

While it is impossible to change one's chronological age, the concept of biological age has gained attention in recent years. Biological age refers to the condition of one's body and the rate at which it is aging, which can be influenced by various factors such as lifestyle and genetics. Research has shown that NMN can raise NAD levels, which can potentially reverse the effects of aging on the body.

One of the most significant effects of NMN supplementation is the increase in energy levels. As people age, they tend to experience a decrease in energy, which can negatively impact their overall health and well-being. NMN has been shown to increase NAD levels, which can boost energy levels and help individuals feel more youthful and vibrant. Additionally, improved cognitive function has been reported in people taking NMN, which can enhance the quality of life and overall productivity.

Metabolism also tends to slow down as people age, which can lead to weight gain and other health issues. NMN can help speed up metabolism, potentially leading to weight loss and a more youthful appearance. In addition, better sleep is another benefit of NMN supplementation, which can further enhance one's overall well-being and quality of life.

While the effects of NMN on physical appearance are still being studied, there is evidence that age-related deteriorations can be improved in mice taking NMN. This has led to speculation that NMN may have similar effects in humans. However, more research is needed to confirm this hypothesis. Researchers are, however, certain about the positive effects of NMN on healthspan, which refers to the length of time a person is able to live a healthy and functional life. By improving various aspects of health and well-being, NMN can potentially extend healthspan and allow people to more fully enjoy their golden years.

Liposomal vs Sublingual vs Oral NMN: Which Method of Consumption Is Better?

At present, no scientific proof exists to indicate that liposomal NMN or sublingual NMN supplements offer superior bioavailability or are more successful in increasing NAD levels compared to oral capsules. In reality, there is a considerable risk linked to lipo NMN due to the lack of research on cellular reactions to it. High bioavailability of NMN via liposomes might have adverse effects on cellular function.

Top research institutions do not utilize liposomal or sublingual NMN supplements for enhancing NAD levels. Oral capsules are the most effective and commonly employed method in all research investigations.

Moreover, concerns regarding the bioavailability and stability of liposomal NMN supplements exist. NMN molecules are surrounded by a highly hydrophilic and concentrated liposomal nano-bubble, which could potentially reduce their stability.

Numerous recent human clinical studies on NMN have verified that NMN is efficiently absorbed by the human digestive system and can elevate blood NAD concentrations. As a result, the most optimal NMN supplements are in oral capsule format to guarantee the highest efficacy and safety.

The Bottom Line

NMN supplements have gained significant attention for their potential to support healthy aging and enhance overall well-being by boosting NAD levels. That means consumers are likely to have more options for NMN supplements. But in order to benefit, make sure you understand exactly what goes into a great product. Our pick for the best NMN supplement of 2023, Wonderfeel Youngr™, stands out for its potent formula, high-quality ingredients, and positive customer feedback.

Disclaimer:

The above is a sponsored post, the views expressed are those of the sponsor/author and do not represent the stand and views of Outlook Editorial.