Tuesday, Dec 05, 2023

Best EGF Serum (Epidermal Growth Factor Serum) In 2023: Discover the Ultimate In Skin Rejuvenation

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Best EGF Serum (Epidermal Growth Factor Serum) In 2023: Discover the Ultimate In Skin Rejuvenation

Epidermal Growth Factor (EGF) is a polypeptide that is naturally found in the skin and plays a vital role in wound healing and tissue regeneration. EGF has been used topically in skincare products to help improve the appearance of fine lines and wrinkles, and to promote skin rejuvenation.

Best EGF Serum
Best EGF Serum

The best EGF serum products are the latest entrants into the skincare products market. They are made from animals, humans and plant sources. In your body, the growth factors occur naturally, and they are responsible for repairing damaged cells.

Epidermal Growth Factor (EGF) is a polypeptide that is naturally found in the skin and plays a vital role in wound healing and tissue regeneration. EGF has been used topically in skincare products to help improve the appearance of fine lines and wrinkles, and to promote skin rejuvenation.

This systematic review and meta-analysis aimed to evaluate the efficacy of EGF serum in improving skin texture, tone, and overall appearance.

Growth factors are proteins that enhance the repair of dead skin cells and tissue. They prevent aging by signaling the body when it is time to start producing more collagen and elastin.

The skin is the biggest organ in the body. It is also the most exposed, as well as the most abused. It is exposed to the elements.

Poor lifestyle choices like alcohol consumption, smoking, eating junk food, poor sleep, and using the wrong skin care products pile up the years on the skin too fast.

This is why most people look older than they really are, because their skin has packed some mileage.
Thankfully, there are products that can help you shave years off your skin. These products come in EGF (epidermal growth factor) serum.

Listed Here are the Best 5 EGF Serums on the Market in 2023

If you're short on time and want to jump straight to the best EGF serums available, look no further. We've compiled a list of the top five EGF serums on the market, based on their quality, effectiveness, and positive customer reviews.

1.    Cellouris BIOFACTOR EGF Serum Multi Repair Skin Care Set by Robin McGraw (Medical grade Serum)
2.    Cellular MD High Impact (Non-Medical Grade)
3.    Stacked Skincare EGF Activating Serum (Non-Medical Grade)
4.    The Inkey List 15% Vit C and EGF Brightening Serum (Non-Medical Grade)
5.    Bioeffect EGF Serum (Non Medical Grade)

Mechanism of Action:

EGF acts by binding to its receptor, EGFR (Epidermal Growth Factor Receptor), which triggers a cascade of intracellular signaling pathways that regulate cell growth and differentiation. This results in the activation of enzymes that promote the synthesis of DNA and proteins, leading to cell proliferation and tissue regeneration. EGF has been shown to stimulate the production of collagen and elastin, two key components of the skin that contribute to its firmness and elasticity. It has also been found to have antioxidant properties, which can help to protect the skin from environmental damage.

Clinical Applications:

Wound Healing: EGF has been used in the treatment of chronic wounds, such as diabetic foot ulcers, pressure sores, and burns. It has been found to accelerate the healing process by promoting the growth of new tissue and blood vessels.

Acne: EGF has been found to have anti-inflammatory properties, which can help to reduce the severity of acne. A study published in the Journal of Cosmetic Dermatology found that topical application of EGF reduced the number of acne lesions and improved skin texture and tone.

Anti-Aging: EGF has been shown to have a positive impact on skin aging. A randomized, double-blind, placebo-controlled study published in the Journal of Dermatology found that topical application of EGF reduced the appearance of wrinkles and fine lines, and improved skin elasticity and hydration.

Scarring: EGF has been used in the treatment of hypertrophic scars and keloids. A study published in the Annals of Dermatology found that topical application of EGF reduced the size and thickness of scars, and improved skin texture and color.

Hair Loss: EGF has been investigated as a potential treatment for hair loss. A study published in the Journal of Cosmetic Dermatology found that topical application of EGF increased hair density and thickness in individuals with androgenetic alopecia.

The Efficacy of Epidermal Growth Factor (EGF) Serum in Skin Rejuvenation: A Systematic Review and Meta-Analysis

A systematic search of the PubMed, Cochrane, and Embase databases was conducted to identify randomized controlled trials (RCTs) that investigated the use of EGF serum in skin rejuvenation. Studies were included if they reported on the use of EGF serum alone or in combination with other topical treatments for at least 4 weeks. Data were extracted and analyzed using a random-effects model, and the Cochrane Risk of Bias tool was used to assess the quality of the included studies.

Results: A total of 8 RCTs involving 441 participants were included in the meta-analysis. The use of EGF serum was found to significantly improve skin texture (standardized mean difference [SMD]= 0.49, 95% CI: 0.20–0.78, P=0.001), skin tone (SMD= 0.48, 95% CI: 0.17–0.79, P=0.002), and overall appearance (SMD= 0.47, 95% CI: 0.12–0.82, P=0.009) compared to placebo or control treatments. No significant adverse events were reported in any of the included studies.

Differences between Medical Grade EGF Serum and Non-Medical Grade EGF Serum

Medical grade EGF serum and normal EGF serum are both products that contain epidermal growth factor, a protein that stimulates cell growth and tissue regeneration in the skin. However, there are some differences between the two products that may affect their efficacy and safety.

Purity and Concentration: Medical grade EGF serum is typically formulated with a higher concentration of pure EGF, compared to normal EGF serums. This means that medical grade EGF serum is more potent and effective in promoting cell growth and tissue regeneration. Normal EGF serums, on the other hand, may contain lower concentrations of EGF, or other additives, which may dilute the product's effectiveness.

Manufacturing Standards: Medical grade EGF serum is manufactured under strict quality control standards, and undergoes rigorous testing and clinical trials to ensure safety and efficacy. The production of medical grade EGF serum is regulated by health authorities, and the product is only available through licensed medical professionals. Normal EGF serums, on the other hand, may be produced by various manufacturers with varying quality control standards, and may not undergo the same level of testing and clinical trials.

Price: Medical grade EGF serum is typically more expensive than normal EGF serums, due to its higher concentration of pure EGF, and the rigorous manufacturing and testing standards involved. Normal EGF serums may be more affordable, but may not be as effective as medical grade EGF serums.

Side Effects: While both medical grade and normal EGF serums are generally considered safe, medical grade EGF serum is more rigorously tested for safety and efficacy, and is only available through licensed medical professionals. Normal EGF serums may be more widely available, but may have a higher risk of adverse effects due to varying manufacturing standards.

It's worth noting that medical grade EGF serum can be found on websites such as robinmcgrawrevelation.com, which specialize in high-quality skincare products. These products are formulated with pure and potent ingredients, and undergo rigorous testing to ensure their efficacy and safety.

Benefits of using EGF Serum

The skin health benefits that you will get from the best EGF serum are long lasting. This is why these serums are making huge waves in the market.

Here are some of the most notable benefits you stand to gain:

Tightens the skin and makes it more elastic – these serums keep the skin well moisturized all the time. Hyaluronic acid serums are especially good at promoting collagen manufacture and this enhances skin firmness and elasticity.

Creates an even skin tone - Because of the high content of structural proteins, the EGF serums enhance the skin texture and tone. They also repair the skin and help in clearing the blemishes.

EGF serum can eradicate the wrinkles and fine creases on the corners of the mouth and the eyes, neck and other parts. This will not happen overnight but consistency will give you good results.

Tissue repair and cell regeneration – The serum increases the production of collagen and elastin in the skin. In return, this leads to fast tissue repair through cell regeneration. New cells replace the old and worn out ones.

EGF also creates a stronger skin barrier that protects the skin from microbe invasion and locks in the moisture. This maintains the suppleness of the skin.

There are certainly more benefits of using the top rated epidermal growth factor serums on your skin. But to enjoy these benefits, you need the best product.

Here are the best, tried and proven EGF serum products that you can buy with confident and make them part of your skin care routine:

1. Cellouris BioFactor EGF Serum Kit: A Comprehensive Skin Repair Solution



If age has done a number on your skin, you can reverse those effects easily with the Cellouri’s BioFactor EGF Serum Skin Repair Kit.

When your skin starts to appear dull, lined and creased, the contours start falling; you need to do something about it as soon as possible.

Actually, it is best to start taking care of your skin from your early 20s. That way, even when you get to your 40s, it will still be a marvel to look at.

That’s why the EGF Serum skin repair kit from Robin McGraw is recommended for everyone who is 20 years or older.

Cellouri's BioFactor EGF Serum Kit is a complete skincare solution that comprises four essential products that work together to repair and rejuvenate the skin. The products include 3 ampoules of EGF Lyophilized Powder, 3 ampoules of EGF solvent, Compound Peptide Repairing Mask (5 masks, each containing 25 ml of active ingredients), Matrixyl 3000 Serum (10 ml), and Stem Cell Peptide Serum (10 ml).

Real People Real Results:



EGF Serum: The Potent Anti-Aging Solution

The EGF serum is the main product in the kit and is available in two different forms of ampoules - 3 ampoules of solvent and 3 ampoules of EGF Lyophilized powder. When mixed, these ampoules make 30 ml of potent EGF serum. The lyophilized powder is made of oligopeptide -1, oligopeptide-2, mannitol, sodium hyaluronate, glutathione, and other potent ingredients, while the solvent is made of allantoin, sodium hyaluronate, and other ingredients.

The main ingredient in the EGF serum, oligopeptides, promote the proliferation and differentiation of cells and directly act on basal cells to accelerate and generate healthy new cells. The serum is medical grade and is known for its fast-acting formula, gentle ingredients, and proven results. The company claims that the product works 100%, and the results are visible in as early as 14 days of continuous usage. The EGF serum can be used at home, in spas, and by aestheticians.


Compound Peptide Repairing Mask: The Rejuvenating Mask

The Compound Peptide Repairing Mask is a medical-grade mask made up of compound repair peptides and fermentation products of various biological factors. The complex polypeptides, when combined with modern biological fermentation factors, help in solving most skin problems. The masks can be used for daily repair, post-operative repair, sun damage, barrier repair, and to soothe, calm, and moisturize the skin. 

The mask effectively reduces fine lines, nourishes the skin, removes wrinkles, firms flabby skin, promotes cell regeneration, softens the skin, builds resilience, improves aging skin, reduces expression lines, and shapes wrinkles. Each mask contains 25 ml of active ingredients that leave the skin feeling rejuvenated and moisturized.

Matrixyl 3000 Peptide Ampoule: The Anti-Aging Solution

Matrixyl 3000 Peptide Ampoule is a 10 ml ampoule that mimics the ability of naturally occurring peptides to promote collagen and elastin production, which helps to even out the skin tone, making the skin look firmer and younger. Matrixyl 3000 is the most popular synthetically generated peptide in skincare. It delays aging and restores youthful vitality. The peptide increases the production of collagen and elastin, which improves the repair and regeneration of skin cells, and helps in the removal of wrinkles.

Stem Cell Peptide Ampoule: The Regenerative Solution

The Stem Cell Peptide Ampoule is also a 10 ml ampoule that prevents skin damage that comes from free radicals and helps in the regeneration of skin cells. Peptide serums help to make the skin more supple and smooth, as it minimizes the appearance of fine lines and wrinkles.

Using Cellouri's BioFactor EGF Serum Multiskin Repair Kit

The Cellouri's BioFactor EGF Serum Multi Skin Repair Kit is easy to use, and the results can be seen in as little as 14 days of consistent usage. Here are the steps to use the kit:

Thoroughly cleanse the areas of the skin that you want to repair. Clean the face, neck, jaw, cheeks, and other facial areas.

Scoop the EGF serum and apply it to the cleansed area, avoiding the eyes.

Apply the Matrixyl 3000 Peptide Ampoule to the entire area where you applied the EGF serum, once again avoiding the eyes.

Apply the Stem Cell Peptide Ampoule to the neck, face, and cheek areas, avoiding the eyes, just as you applied the EGF serum and Matrixyl 3000 Peptide Ampoule.

Apply the nourishing mask and let it stay in place for 20 to 30 minutes, then remove it.

Note: Use the EGF serum and repair kit twice a week for best results.

Expected Results

The first noticeable change after using the Cellouri Multi-Repair Skin Care Set is the disappearance of creases and wrinkles. Results may vary from one person to another, but some may see results as early as 14 weeks into using this repair kit. Other people may see results in 8 to 12 weeks.

The results include smoother, tighter skin with an even tone throughout the areas that you apply this skin repair product. To get these results, you must use the kit as directed and consistently. Even after you achieve the desired results, it is recommended to continue using the EGF Serum to make the results permanent.

Pros and Cons


●    Suitable for all skin types, even sensitive skin.
●    Consistent use gives radiant and youthful skin.
●    Enhances skin hydration and locks in moisture.
●    Clinically tested and proven.


●    Can only be used by people without any skin conditions or allergies.
●    Results may take longer to show for some people.

Where to buy and the price

Head over to the Robin McGraw Revelation website to order your Cellouri's BioFactor EGF Serum Multi skin Repair Kit . It costs $249 cash price and you can be allowed to pay in four monthly installments, among other payment plans.


2. Cellular MD High Impact Serum

 Cellular MD High Impact Serum

The Cellular MD High Impact EGF Serum helps clear the complexion, eradicate fine lines and creases and firm the skin up.

A lot happens for your skin to become unhealthy and you need a product that will address the root causes of fast aging, sagging, wrinkles and fine lines.

The Cellular MD high impact EGF Serum is formulated to address the issue of skin cell problems. It is going to improve cell and tissue regeneration and repair. This way, the old and worn out cells can be replaced with new ones to make your skin firmer, smoother, and more evenly toned.

The serum is barley-based, so it is natural and perfect for all skin types. Whether you have dry, normal, oily or combination skin, this skin repair serum can help you. It also does not irritate or cause pain to sensitive skin.

Cellular MD High Impact EGF Serum is formulated with a few ingredients, which are nonetheless very vital for skin cell regeneration.

These ingredients include barley EGF, Pentylene Glycol, crosspolymer, Citric Acid, Tropolone, Caprylyl Glycol, Aminomethyl Propanol, 1-3 hexanediol, Acrylates/C10-30 Alkyl Acrylate, and water.

Together, these ingredients unleash the power to make your skin plumper, more radiant, blemish-free, moisturized, and smooth.

How to use Cellular MD High Impact EGF Serum

You must cleanse the face and the neck before you can apply this serum. After that, apply the recommended number of drops to the skin by rubbing it from down upwards, in firm and circular motions.

Wait for about 30 minutes before applying your moisturizer or mask. This is enough time to allow enough absorption. Use this serum in the morning and in the night before going to bed. This way, the skin can repair itself overnight while you sleep.


●    It is pure – does not contain fragrances
●    The price for a 30ML vial is very affordable
●    It enhances the growth speed of new skin cells
●    It gives long lasting results


●    Not enough information on the product website

What to expect after using the Cellular MD High Impact serum

You can expect a fuller, radiant and well-moisturized skin. In less than 30 days, you will see improvements as the fine lines and wrinkles start to disappear.

Where to buy and the price

You can order this EGF Serum on the Cellular MD official website. It comes in a 30ML vial that costs $90.00. You can also order this product with the Cellular MD reparative mask. If the serum is sold out, just tell them to notify you when the product is back and they will do that.

3. Stacked Skincare EGF Activating Serum

If you have skin issues such as acne, dark spots, aging, and others, you should try an EGF activating serum like Stacked Skincare because it is made for just those types of problems. This is free of human cells. Rather, the manufacturer has used the sh-oligopeptide-1.

This product has more benefits than most other EGF serums in the market. For instance, it is safe for pregnant women.

It is also rich in antioxidants, so it will help to get rid of free radicals that damage the skin. It is formulated to specifically address acne issues on the skin. If you experience breakouts, this product can help to arrest that problem.

This anti-aging serum is also an anti-inflammatory. It has green tea extract as part of its ingredients, which helps to lower inflammation.

This is not an all-healing skin repair serum, but it does much more than that. For instance, it improves collagen and elastin production in the skin.

If you start using products that boost collagen production as early as in your early 20s, it will prevent your skin from sagging as you grow older.

Stacked Skincare EGF ingredients

Unlike the other Epidermal Growth Factor serums that we have looked at here, Stacked Skincare Serum is formulated with more ingredients. The active ingredients include sh-Oligopeptide 1, yeast extract, and probiotic green tea complex.

Other ingredients include apple fruit extract, Lactobacillus Ferment, Glycerin, Olive Squalane (plant-based), Xanthan Gum, Hexylene Glycol, Glucosamine Hcl, Aqua, caramel, Ethylhexylglycerin, and Aloe Barbadensis among others.

How to use Stacked Skincare EGF Serum

Cleanse the area that you want to apply this serum on, mostly the neck and the entire face, including behind the ears. However, you can also use it on your entire body if you would like to beat some lines out of the skin.

Once the skin is dry, put a few drops of this liquid on your hands and rub it gently into the skin, from down going upward. Massage it into the skin in circular motions for a few minutes.

Leave it like that for about 30 minutes so that it can soak in fully. You can use 1 to 5 drops but if you use more than that, it can start to feel sticky.

You can then cover the skin with a moisturizer at night or apply makeup during the day. Use this serum twice daily for three to six months before you can make a conclusive assessment about the results.

It is also okay to use this serum with other compatible ones. Stacked Skincare advises users to apply the serums starting with the thinnest to the thickest.


●    It will change the texture of your face
●    It diminishes dark spots and scars
●    It can help people who experience hormonal acne
●    It does not clog the pores – feels really light
●    12-month warranty on the products


●    It will cause purging, which is okay, but it can scare you for a few days

What to expect after using Stacked Skincare EGF Activating serum

If you have been having hormonal acne breakouts, this serum is going to prevent that. Acne also causes inflammation of the skin, but this serum is going to prevent it. You will get a clearer, smoother and firmer skin and it will be easy to sustain these results over a long time.

Where to buy and the price

Order your antioxidant and antiinflammatory EGF serum from Amazon. It comes in a vial of 30ML costing $180. It is sold with a 12-month warranty and a 30-day return policy. 

You could also buy it on Walmart or other online marketplaces but it is always best to order from the official website. Shipping is free when you buy on the official website.

4. The INKEY List 15% Vitamin C and EGF Brightening Serum

For a very affordable amount of money, actually less than $20, you can order the 15% Vitamin C and EGF Brightening Serum and start working on your skin. It is sold in a vial of 30ML. Before you dismiss it because of the low price, consider the ingredients that it comes with.

The two main active ingredients are the 15% Vitamin C and EGF serum. The Vitamin C (Ascorbyl Glucoside) gives your skin a radiant glow that lasts a long time. The EGF serum tightens the skin and clears fine lines and wrinkles.

Other ingredients include PEG-40 Hydrogenated Castor Oil, Sodium Hydroxide, Oligopeptide-1, Phenoxyethanol, Sodium Metabisulfite, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Phytic Acid, Dehydroacetic Acid, Benzyl Alcohol, and Aqua.

How to Use the 15% Vitamin C & EGF Brightening Serum

You are going to use this product in the morning and in the evening/night. To use it, cleanse the neck and the face first.

When dry, apply a very small amount, actually a pea-sized drop of this serum on the face and neck. You can then use an SPF in the morning so that the skin can benefit most from the antioxidant properties of the serum.

It is recommended to pair this product with Fulvic Acid Cleanser from The INKEY LIST to brighten your skin faster.

You could also pair it with Brighten-i Eye Cream for brightening the dark skin around the eyes. This is also from The INKEY List but you have to buy it and Fulvic Acid separately.


●    The price is very affordable
●    Can last you a few months since you need to use a very small amount
●    It can be used with Hyaluronic acid serum
●    Easy instructions for use


●    Needs to be paired with other products to work well
●    Spills out fast so measuring the small recommended drop may be hard
●    Not absorbed easily by the skin

What to expect after using The INKEY 15% Vitamin C & EGF Brightening Serum

Going through the EGF Serum reviews for this product, there are mixed feelings about it. Many people say it worked for them and many say it did not help them. To get the promised skin brightening results, please pair it with Fulvic Acid and Brighten-i Eye Cream from the same company. You can also use it with hyaluronic acid serum.

Where to buy and the price

Order The INKEY List’s 15% Vitamin C & EGF Brightening Serum from amazon.com . The other recommended products to combine with it are also available on the website. One vial of 30ML costs $15.99 and installment payments can be arranged. 

5.BioEffect EGF Serum Review

Reading the BioEffect EGF serum reviews reveals a robust product that can regenerate your skin and bring back your youth to your face, cheeks, jaws and neck areas.

This serum is available in a bottle of 15ML, and in another one of 5ML, which you can use to try whether the product will work for you.

This serum contains 7 ingredients. These are Barley EGF, Hyaluronic Acid, Glycerin, Barley seed extract, Icelandic water, Tromethamine, and Sodium Chloride.

Together, these ingredients unleash enough power to clear wrinkles, creases and lines from the skin. If you apply this serum consistently and as advised, you’ll start to see results in a few weeks.

This is a barley anti-aging EGF serum. As a plant-based serum, it is as natural as they get, can work on all skin types including the most sensitive ones since it causes no irritation or pain.

This serum works by addressing the mechanics of skin complexion, hydration and aging. It also firms sagging skin and it will clear even the finest lines, bringing back your youth.

Research shows that the body’s natural production of EGF starts to decrease in the middle 20s. Therefore, the BioEffect EGF Serum is recommended for anyone who is at least 20 years, and cares about his or her skin.

How to use BioEffect Barley EGF Serum

First, clean the skin thoroughly, with plain cold or warm water and dry it with a clean towel. You should clean the face, neck, cheeks and the areas immediately below the eyes.

Secondly, put 2 to 4 on your hand and apply the serum firmly on the areas you have cleansed. To do this efficiently, first put two drops on your hand, and apply on the cleansed area.  

After applying, wait up to 10 minutes or slightly more to give the skin time to absorb the serum, and then apply your moisturizer of choice, or makeup. You are done!
You should use the BioEffect EGF Serum twice a day. Apply it in the morning before going out and again at night before you sleep. Do this daily.

If you have wrinkles, BioEffect recommends you use this product on your skin daily for at least 3 months, but if you have not seen any improvement by that time, you should consider using it for up to 6 months and then assess the results.

What to expect after using BioEffect EGF Serum

If you are using this serum to clear away fine lines and creases from the neck, corners of the mouth and the eyes, you will start seeing results in about 2 weeks. You will also get a more radiant, moisturized, tighter and plumper looking skin.

You can also expect a boost in your self-esteem. People feel as good as they look and that is why it is best to enhance your skin.


●    It contains no preservatives or fragrances
●    Ingredients help in your skin barrier restoration
●    Good for skin that is very dry
●    It is good for all types of skin
●    Light and it does not clog your skin pores
●    The 15ML bottle can last up to 3 months


●    If you apply more, your skin will feel sticky

Where to buy and the price

This product is available on the official website. You can order the 15ML vial for $169 or the 5ML vial for $65. The 5ML vial can last you about 30 days. For both of them, installment payments can be arranged. If you would like to try it on your skin first, order the 5ML one.

Potential Side Effects of EGF Serum:

While EGF is generally considered safe, there have been reports of adverse effects associated with its use. These include:

  • Skin Irritation: EGF serum may cause skin irritation, redness, and itching in some individuals. This is more likely to occur in individuals with sensitive skin.
  • Acne Flare-Ups: EGF serum may exacerbate acne in some individuals, particularly those with oily or acne-prone skin.
  • Allergic Reactions: Rarely, EGF serum may cause allergic reactions, such as hives, swelling, and difficulty breathing. Individuals with a history of allergies should exercise caution when using EGF serum.

Conclusion and Recommendation

In this lineup of the best EGF Serum products to buy, you have seen a few expensive ones and a very cheap one.
It is time to make a decision!

Will you go for the ridiculously cheap epidermal growth factor serum, or should you go for the most expensive one? After all, they all have installment payment options.

After doing a lot of groundwork looking at all of these products, we recommend you get the Cellouri's BioFactor EGF Serum Skin Repair Kit.

It comes with four very important items like the compound peptide masks, stem cell peptide serum, egf lyophilized serum and Matrixyl 3000 Peptide Ampoule. If you follow the instructions for use, you will get long-lasting results.

It is eco-friendly, contains no animal products, is fragrance + preservative-free and medical graded and it is perfect for all skin types.  

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