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Best Cortisol Blockers (2023 Rankings) Top Supplements To Reduce Cortisol & Decrease Stress

This article lists the top 5 best supplements to reduce cortisol levels. They all are made using natural ingredients and are clinically proven safe, causing no allergies or side effects.

Best Cortisol Blockers

Cortisol is an essential stress hormone in our body. The adrenal glands produce this hormone when we are dealing with stressful situations. However, higher cortisol levels can cause unhealthy inflammation and health issues, such as insomnia, depression, anxiety, reduced mental alertness, and weight gain.

Sometimes using natural supplements, meditation, and a healthy diet can help reduce cortisol stress hormones. Research suggests that natural cortisol supplements feature active ingredients sourced from high-quality plants that could minimize anxiety or stress.

This article lists the top 5 best supplements to reduce cortisol levels. They all are made using natural ingredients and are clinically proven safe, causing no allergies or side effects.

What Are The Best Supplements To Reduce Cortisol Levels?

Our research and editorial team has compared all the stress-reducing supplements available on the market and curated a list of only those five formulations that work best in reducing stress and anxiety. We will be discussing them one by one:

●    Nooceptin
●    Xanapril
●    Vyvamind
●    NooCube
●    CortiSync



●    Ingredients Used: Bacopa monnieri extract, L-theanine, Ginkgo biloba extract, Citicoline, Panax ginseng extract, Rhodiola rosea extract, and Lion's mane extract.
●    Side Effects: None reported.
●    Price: It starts at $69.
●    Money-Back Guarantee: 30-day.
●    What's Unique About It: It is a 100% clinical research-backed natural supplement to help reduce anxiety and stress.

Nooceptin is a nootropic supplement that uniquely blends neurochemicals, nutraceuticals, and plant extracts. This dietary supplement is clinically proven to show its effectiveness within 30 days of its consistent usage.

Manufactured in an FDA-restricted facility, Nooceptin contains 100% natural ingredients backed by science to relieve stress and anxiety. This complete cognitive enhancer is specifically designed to help people get more done in a short amount of time. This is why it is one of the most preferred nootropic supplements by students, business people, and entrepreneurs.

Nooceptin formulation is designed to help individuals attain laser-sharp focus, increasing their ability to concentrate on complex tasks. Moreover, consumers will not feel the necessity to take stimulants like caffeine. This dietary supplement can also reduce morning brain fog, helping our mind get more clarity while reducing stress.

Many Nooceptin users have also stated that this supplement has increased their ability to remember and recall new information. The manufacturers recommend using these capsules for at least 90 days to attain enhanced results.



●    Ingredients: Magnesium, Ashwagandha, Korean ginseng extract, Rhodiola rose extract, and GABA.
●    Price: It starts at $69.
●    Money-Back Guarantee: 60 days.
●    What's Unique About It: It is an all-natural formula that dramatically reduces stress.

Xanapril is an over-the-counter anxiety formula clinically proven to reduce stress levels in the shortest amount of time—that, too, without causing any side effects. To ensure the most effective outcome, this dietary supplement is a balance between nature and science.

Moreover, the manufacturers of Xanapril claim that individuals could ingest these pills without needing permission from their healthcare professionals. This supplement is made in an FDA-approved facility and can be legally purchased in the USA.

This clinically safe strength and natural formula can help reduce feelings of stress and anxiety. After taking Xanapril capsules, users can experience improved focus and concentration. As a result, this natural supplement can boost happiness and productivity.

Xanapril can only provide maximum effectiveness if used consistently for a prolonged period. The manufacturers recommend new users try it for at least 60 days.



●    Ingredient Used: Vitamin B6, L-tyrosine, Citicoline, L-theanine, Caffeine anhydrous, and Vitamin B12.
●    Side Effects: No negative impacts.
●    Price: It starts at $74.99.
●    Money-Back Guarantee: 30-day.
●    What's Unique About It: It is a natural over-the-counter stimulant for high-performance adults.

Vyvamind is a fast-acting supplement to reduce cortisol levels. These broad-spectrum over-the-counter capsules are particularly formulated for mentally demanding situations.

Hence, it is a prevalent supplement among programmers, students, gamers, traders, and those who usually work at night.

The 100% natural ingredients in Vyvamind are clinically proven to increase the formation of cell membranes by 26%. Also, the research suggests that it can boost brain energy by 14%.

It is only possible because of the formulation that is a combination of nature and science having pharmaceutical power. Moreover, this supplement contains no fillers or bulking agents, avoiding nasty side effects.

Vyvamind can help individuals get unparalleled clarity and focus. After using this supplement, people can harness maximum brain power and feel energetic throughout the day. This formula can help reduce damage from free radicals and oxidative stress, supporting optimum cortisol levels in the body.

The manufacturers of Vyvamind state some of the benefits of the supplement compounds over time. They recommend consistently using it for at least 2-3 months to maximize the effect.




●    Ingredients Used: Lutemax, Bacopa monnieri, Resveratrol, L-theanine, Oat straw extract, Vitamin B7, Vitamin B11, Vitamin B12, Huperzia serrata, and others.
●    Side Effects: None reported.
●    Price: It starts at $64.99.
●    Money-Back Guarantee: 60 days.
●    What's Unique About It: It is one of the best natural supplements to reduce cortisol levels, helping people boost their brain productivity.

NooCube contains an award-winning functional ingredient known as Lutemax® 2020, which is derived from the marigold plant. This ingredient features three critical eye-brain nutrients that help in supporting various areas of the brain responsible for listening, memory, and visual acuity,


The ingredients of NooCube are sourced from 100% natural plants and herbal extracts. Moreover, they are backed by science to reduce stress and anxiety levels in the human body. The manufacturers claim this brain productivity supplement does not require a doctor's permission to use and contains no artificial ingredients to cause adverse side effects.

NooCube contains 13 natural, science-backed ingredients to help individuals get heightened problem-solving skills. The potent formulation may also diminish the feelings of brain overwhelm while providing enhanced motivation to finish tasks before deadlines. The supplement has also improved memory, focus, and concentration.

Despite this, many NooCube reviews claim after using this supplement; they can sleep better and wake up in a better mood.




●    Ingredients Used: Holy Basil, Sensoril, L-theanine, Lemon balm, Magnolia, Litchi, and Rhodolia.
●    Side Effects: None.
●    Price: It starts at $59.95.
●    Money-Back Guarantee: 67-day.
●    What's Unique About It: It is the best stress-relieving natural supplement doctors recommend to reduce cortisol levels.

PrimeGenix manufactures CortiSync , clinically proven to balance cortisol levels in just two weeks. This potent natural supplement helps reduce various symptoms of high cortisol in our bodies. The symptoms include increased appetite, weight gain, mental fatigue, muscle weakness, and reduced motivation.

The clinically tested formulation of CortiSync is specifically designed for men to help them balance stress hormones in their bodies. It targets the root cause of cortisol, which is the hyper-functioning of adrenal glands.


CortiSync contains adaptogens that have been scientifically proven to normalize the function of adrenal glands to produce cortisol to optimum levels. The PrimeGENIX research team has created this formulation using seven adaptogens having rock-solid evidence for controlling stress levels in the human body.

Moreover, in 12 clinical studies, the patented adaptogen of CortiSync was tested, and the results were terrific. The formula reduced fatigue seven times boosted focus nearly twice, and decreased stress by 62.2%.

Many CortiSync users have also experienced many positive results after using this supplement. They also state that their sleep quality has improved dramatically after consuming these pills.


On What Basis Did We Rank The Best Supplements To Reduce Cortisol?

Our research and editorial team has done extensive research in curating the best natural supplements to reduce cortisol levels. For this, they have considered various vital parameters such as quality of ingredients, doctor formulation, customer reviews, refundability, etc.

Keep reading to know how these parameters have influenced our list of top stress supplements:

Natural Ingredients

Since we have chosen only natural supplements, the quality of their ingredients matters a lot. Our recommended supplements use 100% natural ingredients to help reduce stress, anxiety, and depression. Moreover, they have been backed by scientific research to be highly effective and potent.
Some commonly used natural ingredients in the best cortisol supplements are Korean Ginseng Extract, Ashwagandha, Lion's Mane Extract, Citicoline, L-Theanine, etc.


Doctor Formulation

Only those stress-reducing supplements are added to our list formulated by medical professionals or doctors. They are experts in their fields and know how the overproduction of cortisol can affect our overall health. Hence, they will try to create a natural supplementation that is highly beneficial in eliminating these psychological stressors.

Advertised Benefits

One of the most important parameters we have checked while ranking the best supplements to reduce cortisol is their advertised benefits. Many companies claim their product is the best as it can fight the root cause of stress in our bodies. However, they are not true to their words.


Most of the supplements are not effective enough to provide people with satisfactory results. Some also contain artificial ingredients that can lead to various side effects. We ensure that our recommended list has only those supplements that provide good results as advertised.

Customer Reviews & Testimonials

The best natural supplement to reduce cortisol is the one which has been tested and tried by many people because they would judge better whether a particular supplement work to diminish stress, anxiety, depression, or cortisol levels or not.

Hence, we have read many customer reviews and given this parameter high importance while curating our list of the best cortisol-reducing supplements.


Company's Reputation

How transparent and concerned a company is towards its customers is what tells us about the quality of the products. Hence, we have included only the best natural supplements to reduce cortisol that have a good reputation in the market.

Refund Policy

We are aware that we are all different human beings. Our bodies work differently to a particular food, diet, or supplement. So, it is highly likely that one supplement that might work for one person doesn't work for us.

Hence, a firm refund policy is always a priority. If, in any case, a natural supplement doesn't work for anyone, they can return the product and get their money back to try another stress-reducer supplement.


What Is The Science Behind The Best Cortisol-Reducing Supplements

Let us now delve into the scientific evidence backing the ingredients used in the best cortisol-reducing supplements:

Huperzia Serrata

Huperzia serrata is a type of moss that contains a compound called huperzine A. Huperzine A is a potent inhibitor of an enzyme called acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. By inhibiting this enzyme, huperzine A increases the levels of acetylcholine in the brain, which is essential for memory, learning, and other cognitive functions.

Huperzia serrata has been found to reduce cortisol levels by inhibiting an enzyme called 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which is involved in the production of cortisol.



Lutemax is a natural supplement that contains lutein and zeaxanthin, two powerful antioxidants that have been shown to have various health benefits. A study published in Nutrients in 2018 found that Lutemax can help reduce stress hormone levels in the body. The study involved 59 healthy adults who were given either a placebo or Lutemax for 12 weeks.

The study results showed that the Lutemax participants had lower cortisol levels after the stress tests than those who took the placebo.


Sensoril is rich in antioxidants, which help protect the body against oxidative stress. By increasing antioxidant activity, Sensoril can help protect the brain against oxidative stress and improve overall brain health.


Neurogenesis is the process by which new brain cells are formed. This process is essential for maintaining brain function and preventing cognitive decline. Studies have shown that Sensoril can enhance neurogenesis in the hippocampus, a brain region important for learning and memory.

Holy Basil

Holy basil contains compounds that help the body adapt to stress. One of these compounds is eugenol, which has been shown to have anti-inflammatory and antioxidant properties.

A study published in the Journal of Ayurveda and Integrative Medicine found that eugenol in holy basil helps reduce cortisol levels in the body. Cortisol is a stress hormone released in response to stress, and elevated cortisol levels can lead to various health problems.


Holy basil also has adaptogenic properties, which help the body adapt to stress.


At the core of magnolia's brain-boosting effects is its ability to modulate the activity of neurotransmitters. Specifically, magnolia has been shown to enhance the activity of GABA, a neurotransmitter that helps to regulate mood and anxiety. By increasing GABA activity, magnolia can help reduce stress and promote a sense of calm and relaxation.

In addition to its effects on neurotransmitters, magnolia also appears to have anti-inflammatory and antioxidant properties. By reducing inflammation and oxidative stress, magnolia may help protect the brain from damage and promote overall health.



Citicoline is a naturally occurring compound in the brain. It is known for its ability to improve cognitive function and memory. However, recent studies have shown that it can also help to reduce stress hormone levels in the body.

One specific study conducted in 2018 looked at the effects of citicoline on stress hormone levels in rats. The study found that rats given citicoline had significantly lower cortisol levels, a stress hormone, than those not. The study also found that citicoline helped to reduce anxiety-like behavior in the rats.

Supplements To Reduce Cortisol - Are They Even Worth it?


Various psychological and physiological stress factors can cause adrenal fatigue. It can lead adrenal glands to produce cortisol at higher levels. As a result, our overall health may get adversely affected. In such cases, taking cortisol supplements to reduce its levels may give our body instant relief from anxiety and stress.

However, we only recommend taking natural supplements that contain 100% organic ingredients in a precise manner. It will help us avoid many adverse side effects. Some of those supplements can help fight the root cause of stress in our bodies, helping adrenals to produce optimum cortisol naturally.

As always, we recommend consulting a healthcare provider before using our recommended best supplements to reduce cortisol. Also, we would suggest our readers take these supplements along with a healthy diet and exercise.


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