[NEW] - Best NMN Supplement 2023 – GenF20, PartiQlar, Renue Lipo NMN, Wonderfell, Omre Reviews, Price, Where To Buy NMN?

In a society increasingly focused on longevity, a plethora of advertisements promote products that claim to counteract the aging process, prompting consumers to sift through myriad options in the hope of preserving their youthful appearance and vitality. However, the effectiveness of these anti-aging solutions is not universally consistent.

The market is full of products that claim to combat both intrinsic and extrinsic signs of aging. Among these, nicotinamide mononucleotide (NMN) stands out as a notable anti-aging supplement. This article critically evaluates some of the leading NMN choices available.

Best Product: GenF20 Liposomal NMN

GenF20 Liposomal NMN+ is emerging as a premier manufacturer of superior NMN capsules that are gluten-free, GMO-free, additive-free, preservative-free, soy-free and dairy-free. Adhering to strict GMP and US guidelines, each capsule undergoes comprehensive third-party laboratory evaluations at every stage of production and is under FDA supervision to ensure both safety and potency.

A key benefit of Liposomal NMN+ capsules is their rich antioxidant properties, which promote optimal NAD+ levels and slow down the ageing process. In addition to its premium offering, Liposomal NMN+ extends loyalty incentives by allowing customers to earn points either through referrals or through the length of their subscription.

In terms of cost, GenF20 Liposomal NMN maintains a competitive edge with products priced between $58.95 and $69.95. The 500mg variant is priced at $1 per capsule, while the 300mg alternative is priced at $2 per capsule. So this is definitely our top pick!

Product specifications:

Manufacturer: GenF20 Liposomal NMN
Pros: Independently assessed, satisfaction guarantee, stellar efficacy, premier components
Cons: –
Price: 69,95 USD
Rating: ⭐⭐⭐⭐⭐

GenF20 Liposomal NMN Capsules represent the pinnacle of pharmaceutical excellence, meeting rigorous standards for purity, strength and potency. Free from potential allergens such as gluten, soy and dairy, they are suitable for both vegans and those with allergies. Their minimal side effects underline a safe and effective way to improve health. In conclusion, this product is our top recommendation in our analysis.

>> Click here to go to the official website with original product and discount <<

Second Place: PartiQlar

Enter the distinguished realm of Partiqlar’s Pure NMN, a realm of unparalleled potential. Embark on a transformative quest, enriched by unparalleled health enhancements. PartiQlar NMN transcends typical offerings; it symbolises a beacon of transformative quality and superior standards.

Welcome a new era of vitality and wellness with PartiQlar’s Pure NMN, a product that consistently exceeds expectations. Expertly formulated, it is designed to increase energy, promote rejuvenation and holistic health. In the realm of health supplements, PartiQlar NMN is emerging as a pioneering force, combining unparalleled efficacy with groundbreaking ingenuity.

Dive deep into the wonders of PartiQlar’s Pure NMN and experience a surge of vitality that seamlessly integrates into every facet of your existence. Revel in increased energy and crystalline mental focus. Transition from fatigue to a world of zest, efficiency and fervour. PartiQlar Pure NMN is not just a supplement; it’s a portal to a reinvigorated self.

Product specifications:

Manufacturer: PartiQlar
Pros: Anti-aging properties, augmented energy, enhanced endurance & strength
Cons: –
Price: 71,99 USD
Rating: ⭐⭐⭐⭐⭐

PartiQlar NMN delivers an unparalleled experience, providing unrivalled benefits for peak health and vitality. Through rigorous quality assurance and an enduring commitment to excellence, this superior product consistently outperforms. It boosts vitality, promotes cellular renewal and increases energy levels, enabling people to lead lives of rejuvenated enthusiasm, cognitive acuity and enhanced productivity.

>> Click here to go to the official website with original product and discount <<

Third Place: LIPO NMN – RENUE by Science

Renue Lipo NMN is the first liposomal iteration of NMN. This means that the NMN is encapsulated in a lipid sphere, which could theoretically enhance NMN absorption. At the time of writing, there is no empirical evidence to confirm that liposomal NMN has superior absorption to its conventional NMN powder counterpart. However, it is generally accepted that some supplements show improved absorption when encased in liposomes.

Renue advocates a high quality supplement that contains rice flour and no synthetic additives. Priced at USD 84.95, this product is on the higher end of the market, but we still think it is a reasonable price.

Product specifications:

Manufacturer: RENUE
Pros: Encased in liposomal NMN, Devoid of unnecessary fillers or additives, Verified by independent third-party evaluations, 500mg of NMN per dosage, equivalent to two capsules
Cons: –
Price: 84,95 USD
Rating: ⭐⭐⭐⭐⭐

Renue Lipo NMN introduces a liposomal form of NMN for potentially improved absorption. While there is no concrete evidence yet to support superior absorption over conventional NMN powder, liposomal encapsulation often improves the absorption of supplements. Renue promotes a quality supplement free of synthetic additives, using rice flour.

>> Click here to go to the official website with original product and discount <<

Fourth Place: Wow!Health Ageless

Wow!Health manufactures its NMN supplements in the USA under GMP and HACCP guidelines. These premium nicotinamide mononucleotide capsules are derived from herbal sources and guarantee 100% purity.

Using the latest technology, the supplement’s bioavailability is maximised, ensuring efficient NMN delivery to cells and tissues. In addition to pure NMN, each Wow!Health capsule is enriched with essential trace elements and minerals.

For best results, Wow!Health recommends taking two capsules daily: one in the morning on an empty stomach and one in the afternoon. While free shipping is available within the USA, there is no recurring subscription service. However, attractive discounts are offered to both returning and new customers.

Product specifics:

Manufacturer: Wow!Health
Pros: Refund assurance, plant-derived, optimal efficacy & vegan-friendly
Cons: –
Price: 64,99 USD
Rating: ⭐⭐⭐⭐

Wow!Health, based in the USA, produces high quality NMN supplements under GMP and HACCP protocols. Each vegetarian capsule contains a significant amount of NMN. Using advanced technology, the supplement ensures enhanced bioavailability and is fortified with TMG, trans-resveratrol and vitamins B12 and B9. The brand advocates a daily intake of two capsules and offers free US shipping, attractive discounts and a satisfaction guarantee.

>> Click here to go to the official website with original product and discount <<

Fifth Place: Wonderfeel Youngr NMN

Youngr NMN, a remarkable offering from Wonderfeel, is strategically formulated to support healthy ageing. Infused with antioxidants, sirtuin activators and a robust 900mg NMN dosage, users have noticed improvements in energy, memory recall, skin suppleness and sleep quality. For optimal absorption, it’s recommended to take the supplement during a morning meal rich in healthy fats, which helps to maximise the effectiveness of resveratrol and its anti-aging properties.

Currently, Wonderfeel is extending an introductory price for both subscription models and single purchases, granting a $15 discount and ensuring that the price remains constant. The official Wonderfeel website offers a wealth of user reviews for a full understanding of the product.

It is important to recognise that while NMN supplements offer many benefits, they should not replace medical care. Regular consultation with a healthcare professional remains essential for maintaining good health.

Product details:

Manufacturer: Wonderfeel
Pros: Boasts a patented blend curated by a Harvard MD and delivers a formidable 900mg of NMN per serving. Consumers offer laudatory feedback, highlighting its myriad benefits, including enhanced energy, cognitive function, and skin resilience.
Cons: Limited variety in packaging sizes.
Price: 88,00 USD
Rating: ⭐⭐⭐⭐

Youngr NMN, presented by Wonderfeel, features a distinctive formula accredited by a Harvard MD. This innovative blend seamlessly integrates readily assimilable NMN with fortifying elements to enhance cellular performance and ensure the supplement delivers optimal benefits.

>> Click here to go to the official website with original product and discount <<

What is NMN?

Nicotinamide mononucleotide (NMN) is emerging as a dietary supplement postulated to increase nicotinamide adenine dinucleotide (NAD) levels in human physiology, potentially offering anti-ageing benefits both dermally and systemically.

NAD is central to human health, orchestrating energy metabolism, facilitating DNA damage repair and mediating stress responses.

Although conclusive human studies are still required, preliminary indications suggest that NMN may have a significant impact on age-related facets. These include not only external aesthetics, but also profound internal elements such as vascular integrity, circulatory efficiency, muscular vitality and overall disease susceptibility.

Selecting an Optimal NMN Supplement: A Guideline

When looking for an excellent nicotinamide mononucleotide supplement, look for established brands that provide an adequate NMN concentration and have clear characteristics.

Key considerations include:

• Independent Verification – Look for supplements that have been verified by an impartial third party and adhere to exemplary manufacturing standards, guaranteeing pharmaceutical-grade NMN free of heavy metal contaminants.
• Corporate commitment to supplement purity.
• Customer Service Excellence – Emphasise customer satisfaction and fiscal responsibility as evidenced by customer testimonials that highlight real consumer encounters.
• Economic Viability – Procure a supplement that is in line with your budget, as the efficacy of supplements depends on their consistent and appropriate consumption, implying recurrent purchases.

Following these guidelines will ensure an informed choice of a superior NMN supplement tailored to individual needs.

How NMN & NAD+ Work

Nicotinamide mononucleotide (NMN) is essential for the production of NAD, an essential energy molecule. Its absence would render life unsustainable within moments. This molecule is essential for every cellular function and over 500 enzymatic processes. The core functions of NAD include

• Accelerates recovery processes.
• Engaging anti-aging proteins, namely sirtuins, to mitigate the effects of ageing.
• Facilitating DNA repair through the PARP1 mechanism.
• Promotes muscular development.
• Supports hormone synthesis.
• Increasing energy through the well-known Krebs cycle.
• The body’s natural defence boosters, sirtuins, have captured the imagination of scientists. However, their effectiveness depends on sufficient NAD levels.

As we age, there’s a progressive decline in NAD levels, so that someone in their 50s has about half the NAD levels of a 20-year-old. Reduced NAD levels can accelerate ageing and shorten the life span, highlighting the indispensability of NMN.

NMN, a synthesised nucleotide and immediate precursor of NAD, is essential for optimal cellular function. For an in-depth exploration, we recommend David Sinclair’s insights on the Joe Rogan Experience podcast.

Nicotinamide Mononucleotide (NMN) Benefits

While supplementation with NAD+ addresses specific physiological areas, NMN promotes a comprehensive increase in cellular NAD, revitalising ageing tissues in dire need.

NMN is featured prominently in longevity studies and is attracting considerable attention from doctors and health enthusiasts. It is frequently mentioned in discussions of

• Dr. David Sinclair
• Dr. Josh Axe
• Dr. Eric Berg
• Dr. Mark Hyman
• Dr. Rhonda Patrick
• Dr. Peter Attia

The benefits are derived from both the inherent properties of the molecule and the enhancement of NAD+ levels, with new revelations about its health effects continuing to emerge.

The main health benefits attributed to NMN include:

• Increased energy metabolism
• Defence against diabetes, hepatic steatosis and obesity
• Revitalisation observed in mouse studies
• Increased insulin sensitivity
• Memory enhancement
• Cognitive support in Alzheimer’s patients
• Shield against neurodegenerative disease
• Significant NAD+ increase
• Fat mass reduction
• Lean mass enhancement
• Immunological function enhancement
• Microbial resistance and immune suppression
• Improved circulation
• Potential efficacy against COVID symptoms
• Mimics the benefits of calorie restriction
• Enhances human physiological performance
• Facilitates mobility in the elderly
• Fertility restoration
• Cardiac protection
• Increased mitochondrial vitality
• Promotion of DNA repair
• General wellbeing
• Biological age deceleration

Supplementation with nicotinamide mononucleotide boosts both brain and body defences. Emerging scientific work suggests NMN’s ability to increase NAD and restore organ systems to optimal health.

NMN Delivery Mechanisms: An essential guide for consumers

The efficacy of even the most concentrated NMN depends on its ability to be absorbed. Understanding the delivery mechanism of NMN is crucial as it determines its overall effect, potency, potential adverse effects and associated costs.

Pure NMN	Sublingual NMN	Intranasal NMN	Liposomal NMN
Absorption	Low	Medium	High	High
Duration	Short	Medium	Short	Up to 24 hours
Onset	Slow	Fastest	Fast	Fast
Dose Required	High	Medium	Low	Low
Target	Muscle	Systemic	Brain	Systemic
Feature	Convenience	Noticeable energy boost	Neuroprotective, clears brain fog	Extended release, highest bioavailability
Price	Least expensive	Moderate	Moderate	Most expensive
Value	Low	Low	Medium	Best

Normal NMN Powder

Conventional standard NMN powders are the most cost effective and extensively researched. In particular, most products on the market fall into this category. However, a significant drawback is their poor absorption efficacy.

Gastric acid compromises the integrity of non-fortified NMN and NR, converting them to nicotinamide (NAM) before they reach critical tissues. Increasing the dose of NAD enhancers to counteract this reduced absorption may inadvertently increase NAM levels. Such an increase could be counterproductive to well-being, as it may suppress sirtuins, proteins that are crucial for cellular vitality and longevity.

Sublingual NMN

The sublingual method of NMN administration requires the compound to be dissolved under the tongue. Several companies use advanced techniques to bypass hepatic processing, allowing rapid integration into the circulatory system, which enhances uptake. Typically, this method is more expensive than traditional powders. Many people who use sublingual NMN report an immediate increase in vitality.

However, the exact increase in bioavailability compared to oral intake remains poorly documented in the scientific literature. If you are concerned about the efficacy of your supplement, the apparent effects of sublingual NMN may provide some reassurance.

Intranasal NMN

Nasal delivery of NMN is a novel technique. It clearly bypasses the blood-brain barrier and increases NAD concentrations in cerebral regions. Compared to oral methods, nasal administration requires significantly lower doses, has fewer side effects and exerts a pronounced cerebral influence.

Preliminary studies also suggest its potential for energetic rejuvenation following brain trauma. Due to its limited availability, nasal NMN is more expensive.

Liposomal NMN

Liposomal supplements pave the way for accelerated absorption, bypassing the intestinal degradation that is common with conventional oral variants. This feature is ubiquitous in several supplements, with liposomes providing sustained NMN release, increasing NAD concentrations over a day-long period.

Essentially, liposomes are tiny lipid vesicles, similar to human cell membranes, that resist degradation by gastric acids and promote better distribution throughout the body. An integral technology since the 1960s, liposomal encapsulation is considered by many experts to be a monumental advance.

However, the scientific community is divided on the liposomal method for NMN. Dr Christopher Shade’s studies suggest that liposomes generally increase the absorption of dietary supplements by an estimated three to ten times, providing superior efficacy at reduced dosages. However, liposomal NMN always carries a premium price due to the complexities of production.

NMN Dosage Guidelines

Each NMN product has its own dosage recommendations on the label, and there’s no universally prescribed NMN dosage. For best results, it’s best to take NMN in small doses throughout the day rather than in one large dose.

Nicotinamide mononucleotide is available in several forms: NMN in powder form, encapsulated variants, sublingual preparations and intranasal NMN, which is applied as a nasal spray. It’s thought that the intranasal and sublingual forms may be more effective. The exact quantum of NMN that is beneficial for one person may be different for another. A prudent starting point would be a minimal dosage, gradually increased based on observed health improvements.

However, given the variability in dosage between products, strict adherence to the labelled instructions is imperative. Consultation with a health professional is also strongly recommended before starting any dietary supplement regimen, especially if you are taking medication or other supplements.

Boost your NAD levels naturally

There are two main strategies for increasing NAD levels:

• Supplementation: Precisely formulated enhancers.
• Refinement: Enhancing the inherent mechanism (amplifying the salvage pathway).

The more lasting and profound results are often seen with the second approach.

For those seeking natural modalities to increase NAD levels without resorting to NMN, consider the following:

• Cultivated foods
• Heat therapy sessions
• Periodic food abstinence
• Unprocessed honey
• Lapacho infusion

You could also consider increasing your intake of certain foods containing minute concentrations of NMN:

• Avocado
• Edamame
• Broccoli
• Kale
• Cucumber
• Tomatoes

By incorporating these techniques and dietary elements into your regimen, it’s possible to increase NAD levels naturally, avoiding the need to rely solely on NMN supplements.

Frequently asked questions about NMN

What is NMN’s safety profile?

Studies have confirmed the safety of NMN in animal models. Research in humans to date highlights a remarkable safety profile. Successive studies have confirmed these findings. Even at high doses, NMN has been shown to be non-toxic and safe. However, it is imperative to obtain high quality, uncontaminated products from credible suppliers.

How can you tell if an NMN supplement is working?

For concrete evidence of the quality and efficacy of your NMN supplement, you should consider an intracellular NAD test or an assessment of your „biological age“. Carry out these assessments before you start supplementation and then again after six months.

What is the optimal dose of NMN?

Scientific evidence suggests that an appropriate dose of nicotinamide mononucleotide is between 100 mg and 500 mg daily, depending on the formulation. Some specialists recommend higher doses, approaching 1,000 mg daily. It is worth noting that potential adverse effects, although rare, tend to increase with higher doses.

NMN versus NR: Which is better?

NMN is more stable than NR and therefore offers greater health benefits. For NR to be utilised, the body must first convert it to NMN. If the conversion enzyme NRK falters, the ability of NR to increase NAD levels is reduced. Many experts in longevity research favour NMN over NR.

Why NMN over direct NAD supplementation?

Paradoxically, direct supplementation with conventional NAD powder is proving inefficient. The molecular structure is large, leading to rapid degradation. However, advances such as liposomal and intranasal NAD delivery systems have overcome these challenges and proved effective.

What are the possible adverse effects of NMN?

Scientific research has not yet identified any significant adverse effects of NMN supplementation within recommended limits. However, it’s been documented that nicotinamide riboside could potentially impair athletic performance. Therefore, athletes may be more inclined to use NMN rather than NR.

Could MIB-626 replace NMN?

MIB-626, an innovative and stable NAD enhancer developed by David Sinclair’s MetroBiotech, is being rigorously investigated for its potential in maintaining muscle mass, improving cognitive function and slowing ageing. Because it’s still in its early stages, it’s patentable and offers Metro considerable revenue potential. Comparative research on MIB-626 is scarce compared to the vast compendium of studies on NMN.

Is it beneficial to take trimethylglycine (TMG) with NMN?

It is reasonable to consider co-administering an amino acid called betaine (also known as TMG) with NMN to augment the body’s own methylation processes. TMG has been postulated to mitigate potential adverse effects, particularly when using oral NMN powder for prolonged periods. The need for TMG appears to be reduced with liposomal and sublingual NMN variants.

Main NMN supplements to boost NAD levels

Insufficient levels of NAD would make human survival untenable within moments. As you read this article, there’s no immediate danger. However, many people, perhaps unintentionally, operate below their optimal capacity due to modest deficiencies in this vital cellular compound.

As a result, a significant number of respected longevity and anti-aging scientists are incorporating nicotinamide mononucleotide into their daily regimes. NMN stands out as the leading NAD supplement on the market today. Numerous testimonials highlight remarkable improvements in vitality and overall wellbeing upon its use.

It’s advisable for newcomers to start with inexpensive NAD+ precursor supplements. However, certain genetic markers and lifestyle preferences may require increased supplementation:

• RS1319501 (NAMPT)
• RS9770242 (NAMPT)

For a more accurate understanding, consider undergoing an intracellular NAD assessment, which provides a timely picture of your current levels. A follow-up assessment after 3-6 months of supplementation can provide insight into the authenticity and efficacy of the supplement.

A comprehensive assessment of one’s inherent physiological requirements can lead to informed decisions about the prudence of allocating substantial funds to NMN products.

Unfortunately, the market is flooded with fake and adulterated NAD supplements. Some may lack NMN altogether. Venturing into these dubious products is not only a waste of financial resources, but also poses significant health risks. Choose high-quality supplements from reputable manufacturers to slow down the ageing process, boost energy levels and optimise wellbeing.

Sources

1. https://pubmed.ncbi.nlm.nih.gov/28417163/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818067/
3. https://pubmed.ncbi.nlm.nih.gov/25120628/
4. https://pubmed.ncbi.nlm.nih.gov/31685720/
5. https://www.nmn.com/precursors/nmn-benefits-side-effects-dosage

  

Disclaimer: The above is a sponsored post, the views expressed are those of the sponsor/author and do not represent the stand and views of Outlook Editorial.