Basu was 91 and is survived by two daughters. Her only son died earlier.
Basu was admitted to the nursing home on September 26 following a respiratory tract infection.
She died at 5.40 am this morning, family sources said.
Married to litterateur Buddhadeb Basu in 1934, she penned fiction articles, and travelogues in Bengali.
She began her career as writer with her first book 'Madhabir Janye' in 1940 and wrote over 150 titles which brought her fame and recognition.
Basu nee Ranu Shome who was born in Dhaka, took lessons from Kazi Nazrul Islam, Dilip Kumar Roy (son of D L Roy) and Rabindra Nath Tagore.