As Clooney bagged the Best Actor in a Motion Picture - Drama award for his role in 'The Descendants', beating superstars like Leonardo DiCaprio and Brad Pitt, Streep won the Best Performance by an Actress in the same category for her performance as Margaret Thatcher in 'The Iron Lady'.
'The Descendants' was nominated alongside 'The Help', 'Hugo', 'The Ides Of March', 'Moneyball' and 'War Horse'.
Queen of pop Madonna's track 'Masterpiece' from her directorial venture 'W.E.' proved to be one as she took home the Best Original Song - Motion Picture trophy for it.
Oscar winner Kate Winslet grabbed a globe for her performance in the mini series 'Mildred Pierce'.
Veteran filmmaker Martin Scorsese clinched the Best Director - Motion Picture for his 'Hugo', while Woody Allen took home the Best Screenplay award for 'Midnight In Paris'.
Jean Dujardin was named the Best Actor in a Comedy Or Musical for his performance in 'The Artist', which was named the Best Motion Picture - Comedy Or Musical.
The film was nominated alongwith '50/50', 'Bridesmaids', 'Midnight In Paris' and 'My Week With Marilyn', whose lead star Michelle Williams won in the Best Performance by an Actress in a Motion Picture - Comedy Or Musical category.
'The Adventures Of Tintin' was named the Best Animated Feature Film, ahead of 'Arthur Christmas', 'Cars 2', 'Puss In Boots' and 'Rango'.
Veteran actor Morgan Freeman was honoured with the Cecil B DeMille Award.
The Best Foreign Language Film award went to Iranian picture 'A Separation' by Asghar Farhadi. It left behind Angelina Jolie's 'In The Land Of Blood And Honey', Christian Bale-starrer 'The Flowers Of War', 'The Kid With A Bike' from Belgium and 'The Skin I Live In' from Spain.
Octavia Spencer was awarded the Best Performance by an actress In A Supporting Role prize for 'The Help' as 82-year-old Christopher Plummer took home the same prize in the male category for his performance in 'Beginners'
The Best Original Score - Motion Picture award was given to Ludovic Bource for his work in 'The Artist', which was nominated alongside 'W.E.', 'The Girl With The Dragon Tattoo', 'Hugo' and 'War Horse'.
'Modern Family' was awarded the Best Television Series - Comedy or Musical prize, while 'Homeland' became the Best Television Series - Drama. The latter's star Claire Danes grabbed a golden globe in the Best Performance by an Actress In A Television Series - Drama category.
Kelsey Grammer was handed the Best Performance by an Actor In A Television Series - Drama trophy for 'Boss'.
'Mildred Pierce' might have got Kate Winslet an honour but it lost out in the Best Mini-Series Or Motion Picture Made for Television category to 'Downton Abbey (Masterpiece)'.
Laura Dern won the Best Performance by an Actress In A Television Series - Comedy Or Musical for 'Enlightened', as Matt LeBlanc won in the male category for his role in 'Episodes'.
The Best Performance by an Actor in a Mini-Series or Motion Picture Made for Television award went to Idris Elba for 'Luther', while Jessica Lange won the female category for 'American Horror Story'.
Hosted by Ricky Gervais, the Golden Globes awards by the Hollywood Foreign Press Association was held at the Beverly Hilton hotel.
The full list:
Best Actor, Drama: George Clooney, "The Descendants"
Best Actress, Drama: Meryl Streep, "The Iron Lady"
Best Actor, Musical or Comedy: Jean Dujardin, “The Artist”
Best Director: Martin Scorsese, “Hugo.”
Best Actress, Musical or Comedy: Michelle Williams, “My Week With Marilyn.”
Best Supporting Actor: Christopher Plummer, “Beginners.”
Best Supporting Actress: Octavia Spencer, “The Help.”
Best Foreign Language Film: “A Separation.”
Best Animated Film: “The Adventures of Tintin.”
Best Screenplay: Woody Allen, “Midnight in Paris.”
Best Original Score: Ludovic Bource, “The Artist.”
Best Original Song: “Masterpiece” (music and lyrics by Madonna, Julie Frost, Jimmy Harry), “W.E.”
Best Series, Drama: “Homeland,” Showtime.
Best Series, Musical or Comedy: “Modern Family,” ABC.
Best Actor, Drama: Kelsey Grammer, “Boss.”
Best Actress, Drama: Claire Danes, “Homeland.”
Best Actress, Musical or Comedy: Laura Dern, “Enlightened.”
Best Actor, Musical or Comedy: Matt LeBlanc, “Episodes.”
Best Miniseries or Movie: “Downton Abbey (Masterpiece),” PBS.
Best Actress, Miniseries or Movie: Kate Winslet, “Mildred Pierce.”
Best Actor, Miniseries or Movie: Idris Elba, “Luther.”
Best Supporting Actress, Series, Miniseries or Movie: Jessica Lange, “American Horror Story.”
Best Supporting Actor, Series, Miniseries or Movie: Peter Dinklage, “Game of Thrones.”