Advertisement
Monday, Nov 29, 2021
Outlook.com
Outlook.com

IISER researchers develop new technology to help in precise surgery, treatment of cancer patients

IISER researchers develop new technology to help in precise surgery, treatment of cancer patients
outlookindia.com
1970-01-01T05:30:00+0530
New Delhi, Jun 7 (PTI) Researchers at the Indian Institute of Science Education and Research (IISER) in Bhopal have developed a technology to help in precise surgery and treatment of tumour in cancer patients.

According to the team, the technology can deliver active molecules to specific sections of proteins and hence, can help get rid of the tumours without harming the patient''s healthy cells.

The development of the Linchpin Directed Modification (LDM) platform has been described in three papers published in the Journal of the American Chemical Society, Angewandte Chemie and Chemical Science.

"Successful platforms for precision engineering of proteins depend on the core understanding of molecular and social behaviour of proteins in the chemical reactions.

"Protein modifications typically involve attaching specific chemicals to strategic sections of the proteins. Such protein modifications are commonly seen in nature, but the intricate machinery is challenging to replicate in the lab," said Vishal Rai, Associate Professor, Department of Chemistry, IISER Bhopal.

"The difficulty in attaching specific tags, markers, and therapeutic molecules to specific protein regions arises from the complexity of the protein structure and the non-specific nature of many of the modifiers," Raj added.

The LDM platform is empowered by reagents made of three key components. A key advantage of the LDM platform is that it does not modify the structure or functions of the native protein, he said.

The LDM reagents can precisely label biologically active molecules such as antibodies that can be delivered accurately at the designated cells. The research team has shown that the LDM molecule successfully delivers homogeneous conjugate of a monoclonal antibody and drug for selective inhibition of breast cancer cells.

"The LDM platform provides unprecedented control over precision in protein engineering and a very powerful chemical toolbox for biology and medicine. The platform will help cancer patients with precise imaging-guided tumour surgeries and directed cancer chemotherapeutics in the coming years. In other words, the technology would empower us to get rid of the tumours without harming the patient''s healthy cells," he added. PTI GJS SMN


Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI

More from Website

Ramkumar Ramanathan Wins Maiden ATP Challenger Tour Singles Title In Manama

Ramkumar Ramanathan Wins Maiden ATP Challenger Tour Singles Title In Manama

Ramkumar Ramanathan, who had lost six ATP Challenger finals in his career before, beat Russia's Evgeny Karlovskiy 6-1 6-4 in 68 minutes to claim his singles maiden title.

ISL 2021-22: Bengaluru FC, Kerala Blasters Share Spoils After Bambolim Thriller

ISL 2021-22: Bengaluru FC, Kerala Blasters Share Spoils After Bambolim Thriller

In a space of four minutes, Ashique Kuruniyan scored twice, but strangely for both sides. He opened the scoring in the 84th minute for Bengaluru FC, then levelled it in the 88th minute for Kerala Blasters in their ISL 2021-22 match.

IND Vs NZ, 1st Test: Shreyas Iyer Joins Elite Club - Day 4 Statistical Highlights

IND Vs NZ, 1st Test: Shreyas Iyer Joins Elite Club - Day 4 Statistical Highlights

Shreyas Iyer, who scored 105 runs and 65 runs in the first Test against New Zealand, is the first Indian to score a century and fifty in a debut Test match. With the century, he became the 16th Indian batter to score a hundred on debut.

More from Outlook Magazine

Of Protests, Heart Attack And Success: 74-Year-Old Farmer Recalls Her Journey From Amritsar To Singhu

Of Protests, Heart Attack And Success: 74-Year-Old Farmer Recalls Her Journey From Amritsar To Singhu

A 74-year-old woman from Amritsar narrates how she braved social prejudice, bitter cold and a heart attack to stay put at Singhu border with other protestors.

Dissent Is A Work Of Art

Dissent Is A Work Of Art

As a medium of ethical intervention, art has been pivotal in conveying messages of recent protests to the masses

From Arab Spring To Anti-Covid Stir, How The World Is Protesting

From Arab Spring To Anti-Covid Stir, How The World Is Protesting

Democracy is straining at the seams as authoritarian governments across the world lock horns with citizens.

Advertisement

Outlook Newsletters

Advertisement
Advertisement