From K J M Varma
beijing, Mar 18 Chinese researchers have discovered that a drug used to treat diabetes could be effective against a form of deadly breast cancer, state media reported today.
It has a tendency to quickly spread or metastasize to the brain and lungs. There are currently no effective targeted therapies for this form of breast cancer, which is therefore often fatal, according to Dong.
Dong and his colleagues found that the levels of a metabolic enzyme called AKR1B1 were significantly elevated in triple-negative breast cancer cells, and that this was associated with increased rates of metastasis and shorter survival times, Xinhua news agency reported.
The researchers also found epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat diabetic complications, was able to block the growth and metastasis of the cancer cells.
Dong said the finding is still in the experimental stage.
Whether epalrestat can be applied to the clinical treatment still needs further tests.
A detailed research article in this regard was published on March 7 in the Journal of Experimental Medicine.