RU58841 Hair Loss Treatment: Benefits, Side Effects, Dose, & More

Learn more about RU58841, which is a research compound used for hair loss. We cover the benefits, side effects, dosage guidelines, user results, and much more.

RU58841 Hair Loss Treatment: Benefits, Side Effects, Dose, & More

RU58841 is a research chemical that was originally developed to treat pattern hair loss. It has generated a lot of interest in the search for effective hair loss treatments.

With the introduction of RU58841, there is now new hope for individuals who are looking for treatments that go beyond the traditional options available.

In order to fully understand the potential of RU58841 in addressing hair loss issues, it is crucial to explore its various aspects in detail and evaluate them thoroughly.

Throughout this article, we’ll discuss everything you need to know, including its benefits, side effects, dosage, how to take it, where to buy, and much more.

What is RU58841?

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RU58841 is a research chemical that was originally developed to treat pattern hair loss. It is also known by its chemical name, 4-{4-[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)benzyl]-1-piperazinyl}butyronitrile.1 2

It is classified as a nonsteroidal topical antiandrogen.3 It works by blocking the androgen receptors in the scalp, which helps to prevent the binding of dihydrotestosterone (DHT).4 DHT is a hormone that plays a key role in male pattern baldness. By inhibiting the effects of DHT on hair follicles, RU58841 can help to slow down hair loss and promote hair growth.5

It's considered a research chemical because it has not been approved by regulatory authorities for use as a medical treatment. It is primarily used in scientific studies and experiments to investigate its potential as a hair loss treatment. However, it has gained popularity among individuals seeking alternative options for managing hair loss.

It was initially developed by researchers at the pharmaceutical company Roussel-Uclaf in the 1980s. The compound was synthesized with the intention of treating androgen-related conditions, including pattern hair loss. Despite promising results in early studies, further development of RU58841 as a commercial product was halted.

Although RU58841 is not approved for medical use, it has gained attention as a potential treatment option for pattern hair loss due to its antiandrogen properties. Many believe that it can effectively combat the effects of DHT on the scalp and help to prevent further hair loss.

RU58841 Benefits, Dose, and Side Effects

RU58841 is a research chemical that shows promise in the treatment of pattern hair loss. It works as a nonsteroidal topical antiandrogen, meaning it blocks the effects of androgens (male hormones) on the scalp. Let's dive into the benefits, dosage schedule, and side effects so you can learn more about what to expect.

Benefits of Using RU58841

1. Effectiveness in Preventing Hair Loss and Promoting Hair Growth: One of the key benefits of RU58841 is its ability to prevent hair loss. By blocking the androgen receptors on hair follicles, it inhibits the negative effects of dihydrotestosterone (DHT), a hormone responsible for male pattern baldness. This can help maintain existing hair and prevent further thinning. Additionally, it has shown to promote hair growth by stimulating the anagen (growth) phase of the hair cycle.

2. Potential for Regrowing Lost Hair: While RU58841 is primarily used as a preventive measure, some users have reported regrowth of lost hair. This means that it may have the potential to reverse hair loss to some extent. However, it's important to note that individual results may vary.

3. Improvement in Overall Hair Quality and Thickness: Users have also reported improvements in overall hair quality and thickness with the use of RU58841. This can include increased hair density, stronger strands, and improved texture.6 7

Recommended Dosage of RU58841

Finding the right dose for you is essential when using RU58841. The recommended dosage ranges from 5 to 50 mg per day, depending on individual factors such as severity of hair loss and personal tolerance.

When applying it topically, it's generally advised to use 10-20 mg per application. The solution should be evenly distributed on the scalp, focusing on areas prone to hair loss. It's important to follow the instructions provided by the manufacturer or consult with a healthcare professional for personalized guidance.

Tips for Topical Application (10-20 mg)

When using RU58841 topically, the typical dosage ranges from 10 to 20 mg. Follow these guidelines for proper application:

1. Measure the correct amount of RU58841 using a milligram scale or dropper.

2. Apply the solution evenly to your scalp, focusing on areas where hair loss is most noticeable.

3. Gently massage the product into your scalp to enhance absorption.

4. Use RU58841 consistently according to the recommended frequency (e.g., once or twice daily).

By understanding the recommended dosage range and implementing appropriate application techniques, individuals can optimize their experience with RU58841 while minimizing the risk of potential side effects.

It's worth noting that the dosage range for RU58841 (5-50 mg per day) is significantly higher than what is typically recommended for feminizing hormone therapy (usually in the range of 2-10 mg per day). This underscores the importance of understanding the specific purpose and context in which these medications are being used.


Similarly, it's important to recognize that it's just one of several options available when it comes to anti-androgen therapy for hair loss. As you explore the potential benefits of RU58841, it's important to consider how its recommended dosage aligns with your unique needs and circumstances. With an informed approach to dosage and application, individuals can harness the potential of RU58841 as part of their hair loss management strategy without compromising safety or effectiveness.8

Potential Side Effects of RU58841

While RU58841 has shown promising results as a hair loss treatment option, it is important to be aware of the potential side effects that may occur. However, it's important to note that reported side effects are generally rare and mild. Here are some common side effects associated with RU58841:


1. Skin Irritation: Some users have reported experiencing skin irritation, redness, or itching at the site of application. This can be managed by using a lower dose or applying the product less frequently.

2. Dry Scalp: It can cause dryness of the scalp, leading to flakiness and discomfort. Using a moisturizing shampoo or conditioner can help alleviate this symptom.

3. Hair Shedding: In some cases, initial use of RU58841 may cause temporary hair shedding. This is often referred to as a "shedding phase" and is a sign that the treatment is working. Hair usually regrows stronger and thicker after this phase.

4. Hormonal Imbalance: As an antiandrogen, RU58841 works by blocking the effects of male hormones on the hair follicles. While this can be beneficial for hair loss prevention, it may also impact other hormone-related functions in the body. It is important to monitor for any signs of hormonal imbalance such as changes in libido or mood swings.


To minimize the risk of side effects and manage any adverse reactions, there's a few things you can do. For starters, it's a good idea to start off with a low dose. Begin with the lowest effective dose (around 5 mg per day) and gradually increase if necessary.

Also, you should apply RU58841 topically as directed, typically using 10-20 mg per application.

In addition, you should be monitoring your body's response to the dose. Pay attention to any changes or discomfort you experience while using RU58841. If any side effects persist or worsen over time, consult with a healthcare professional.


Lastly, consider combining with other treatments. It can (and often is) be used in conjunction with other hair loss treatments such as minoxidil or finasteride. However, it is important to consult with a healthcare professional before combining treatments to ensure safety and efficacy.

By being aware of the potential side effects and taking necessary precautions, you can make an informed decision about using RU58841 as a hair loss treatment option. Remember, individual response may vary, and it is always best to consult with a healthcare professional before starting any new treatment regimen.

User Experiences and Results with RU58841

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When it comes to evaluating the effectiveness of any hair loss treatment, user experiences and testimonials play a crucial role. RU58841 has gained attention in the hair loss community, and many individuals have shared their results after using this research chemical. Let's delve into some key points regarding user experiences with RU58841:

Collecting and Analyzing User Experiences and Testimonials

● Numerous online forums and communities provide platforms for users to share their experiences with RU58841.

● These firsthand accounts offer valuable insights into the potential benefits and drawbacks of using RU58841 for hair loss treatment.

● Analyzing a wide range of user experiences allows us to understand the various outcomes people have achieved with this compound.


Exploring Reported Results in Terms of Hair Regrowth and Quality Improvement

● Many users report positive outcomes in terms of hair regrowth while using RU58841.

● Some individuals notice a reduction in hair shedding and an increase in overall hair density.

● It may also contribute to improving hair quality, making it thicker, stronger, and healthier.

It's important to note that individual responses to RU58841 can vary, as with any hair loss treatment. Factors such as genetics, underlying health conditions, and adherence to proper dosage and application methods can influence the results achieved.

Understanding user experiences with RU58841 can provide valuable insights for those considering this treatment option. However, it's essential to approach these testimonials with caution, as individual experiences may not be representative of everyone's results.


RU58841 Summary

While RU58841 shows promise as a nonsteroidal topical antiandrogen for addressing pattern hair loss, its future as a mainstream treatment option depends on substantial research advancements. The current limitations underscore the necessity for in-depth investigations into its long-term safety and efficacy. As ongoing studies continue to unravel the potential of RU58841, it remains an intriguing avenue for exploring innovative solutions in the realm of hair loss treatments.

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1. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D. RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. doi: 10.1016/0960-0760(94)90250-x. PMID: 8136306.


2. De Brouwer B, Tételin C, Leroy T, Bonfils A, Van Neste D. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice. Br J Dermatol. 1997 Nov;137(5):699-702. PMID: 9415227.

3. Marks DH, Prasad S, De Souza B, Burns LJ, Senna MM. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris. Am J Clin Dermatol. 2020 Apr;21(2):245-254. doi: 10.1007/s40257-019-00493-z. PMID: 31832993.

4. Cardoso CO, Tolentino S, Gratieri T, Cunha-Filho M, Lopez RFV, Gelfuso GM. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence. Clin Cosmet Investig Dermatol. 2021 May 12;14:485-499. doi: 10.2147/CCID.S284435. PMID: 34012282; PMCID: PMC8126704.


5. Pan HJ, Wilding G, Uno H, Inui S, Goldsmith L, Messing E, Chang C. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine. 1998 Aug;9(1):39-43. doi: 10.1385/ENDO:9:1:39. PMID: 9798729.

6. Nestor MS, Ablon G, Gade A, Han H, Fischer DL. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021 Dec;20(12):3759-3781. doi: 10.1111/jocd.14537. Epub 2021 Nov 6. PMID: 34741573; PMCID: PMC9298335.

7. Asfour L, Cranwell W, Sinclair R. Male Androgenetic Alopecia. [Updated 2023 Jan 25]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.


8. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Antiandrogens. [Updated 2014 Jun 10].

Disclaimer: The above is a contributor post, the views expressed are those of the contributor and do not represent the stand and views of Outlook Editorial.